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Styxl2 Gene Detail
Summary
  • Symbol
    Styxl2
  • Name
    serine/threonine/tyrosine interacting like 2
  • Synonyms
    C130085G02Rik, Dusp27
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685055
    NCBI Gene: 240892
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:165925717-165955467 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    997 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685055
 protein coding gene Chr1:165925717-165955491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016700
 protein coding gene Chr1:171617122-171649871 (-)
A/J MGP_AJ_G0016681
 protein coding gene Chr1:164627216-164656892 (-)
AKR/J MGP_AKRJ_G0016647
 protein coding gene Chr1:169594233-169627265 (-)
BALB/cJ MGP_BALBcJ_G0016642
 protein coding gene Chr1:165103805-165133421 (-)
C3H/HeJ MGP_C3HHeJ_G0016466
 protein coding gene Chr1:169816741-169849901 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017103
 protein coding gene Chr1:177367805-177398962 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014812
 protein coding gene Chr1:156498275-156527765 (-)
CAST/EiJ MGP_CASTEiJ_G0016046
 protein coding gene Chr1:169411342-169446413 (-)
CBA/J MGP_CBAJ_G0016441
 protein coding gene Chr1:183679883-183714612 (-)
DBA/2J MGP_DBA2J_G0016547
 protein coding gene Chr1:163492399-163523252 (-)
FVB/NJ MGP_FVBNJ_G0016545
 protein coding gene Chr1:161929540-161959386 (-)
LP/J MGP_LPJ_G0016618
 protein coding gene Chr1:172697574-172730602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016570
 protein coding gene Chr1:191130107-191161495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017139
 protein coding gene Chr1:169460920-169492552 (-)
PWK/PhJ MGP_PWKPhJ_G0015832
 protein coding gene Chr1:162697852-162729193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015619
 protein coding gene Chr1:168305264-168334998 (-)
WSB/EiJ MGP_WSBEiJ_G0016108
 protein coding gene Chr1:169597971-169630326 (-)



Homology
more
  • Human Ortholog
    STYXL2, serine/threonine/tyrosine interacting like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STYXL2, serine/threonine/tyrosine interacting like 2
  • Synonyms
    DUSP27
  • Links
    NCBI Gene ID: 92235
    neXtProt AC: NX_Q5VZP5
    UniProt: Q5VZP5

  • Chr Location
    1q24.1; chr1:167094075-167129165 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 6 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete lethality throughout fetal growth and development, edema in some dead fetuses, and severe disruption of the sarcomeric structures in fetal cardiomyocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    15
  • cDNA Data
    22
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240892 NCBI Gene Model | MGI Sequence Detail 29751 C57BL/6J ±  kb
    transcript NM_001033344 RefSeq | MGI Sequence Detail 4042 C57BL/6  
    polypeptide Q148W8 UniProt | EBI | MGI Sequence Detail 1138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006751 serine/threonine/tyrosine-interacting-like protein 2
      (term hierarchy)
    • InterPro Domains
      IPR020405 Atypical dual specificity phosphatase, subfamily A
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000387 Tyrosine-specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:7414005
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:351096 Chen X, et al., Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. Elife. 2024 Jun 3;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory