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Gpr55 Gene Detail
Summary
  • Symbol
    Gpr55
  • Name
    G protein-coupled receptor 55
  • Synonyms
    CTFL, LOC227326
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685064
    NCBI Gene: 227326
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:85866039-85888729 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    646 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685064
 protein coding gene Chr1:85860927-85924781 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016238
 protein coding gene Chr1:87161273-87183899 (-)
A/J MGP_AJ_G0016219
 protein coding gene Chr1:83940573-83963168 (-)
AKR/J MGP_AKRJ_G0016180
 protein coding gene Chr1:86369600-86392335 (-)
BALB/cJ MGP_BALBcJ_G0016176
 protein coding gene Chr1:84058583-84081596 (-)
C3H/HeJ MGP_C3HHeJ_G0016004
 protein coding gene Chr1:86627143-86649916 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016632
 protein coding gene Chr1:90491355-90513985 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014354
 protein coding gene Chr1:78434049-78457840 (-)
CAST/EiJ MGP_CASTEiJ_G0015589
 protein coding gene Chr1:85860451-85883175 (-)
CBA/J MGP_CBAJ_G0015980
 protein coding gene Chr1:93306146-93328794 (-)
DBA/2J MGP_DBA2J_G0016082
 protein coding gene Chr1:83250104-83272677 (-)
FVB/NJ MGP_FVBNJ_G0016082
 protein coding gene Chr1:82294865-82318449 (-)
LP/J MGP_LPJ_G0016154
 protein coding gene Chr1:88273253-88299960 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016108
 protein coding gene Chr1:96597994-96621804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016675
 protein coding gene Chr1:86496044-86518659 (-)
PWK/PhJ MGP_PWKPhJ_G0015376
 protein coding gene Chr1:82531707-82555074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015156
 protein coding gene Chr1:85481761-85504274 (-)
WSB/EiJ MGP_WSBEiJ_G0015653
 protein coding gene Chr1:86144634-86168283 (-)



Homology
more
  • Human Ortholog
    GPR55, G protein-coupled receptor 55
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR55, G protein-coupled receptor 55
  • Synonyms
    LPIR1
  • Links
    NCBI Gene ID: 9290
    neXtProt AC: NX_Q9Y2T6
    UniProt: Q9Y2T6

  • Chr Location
    2q37.1; chr2:230907318-230961201 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 5 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased bone volume due to impaired osteoclast function in male mice. Female mice exhibit a milder phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    69
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049608 Ensembl Gene Model | MGI Sequence Detail 22691 C57BL/6J ±  kb
    transcript ENSMUST00000086975 Ensembl | MGI Sequence Detail 3722 Not Applicable  
    polypeptide ENSMUSP00000084196 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 44
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:351975 Gajghate S, et al., GPR55 Inactivation Diminishes Splenic Responses and Improves Neurological Outcomes in the Mouse Ischemia/Reperfusion Stroke Model. Cells. 2024 Feb 3;13(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory