Mideas MGI Mouse Gene Detail - MGI:2685106 - mitotic deacetylase associated SANT domain protein

Symbol

Mideas
Name

mitotic deacetylase associated SANT domain protein
Synonyms

9430029N19Rik, C130039O16Rik, Elmsan1

Feature Type

protein coding gene
IDs

MGI:2685106
NCBI Gene: 238317
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr12:84195950-84265655 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.07 cM
Mapping Data

2 experiments

SNPs within 2kb

1632 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685106	protein coding gene	Chr12:84195942-84265679 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019930	protein coding gene	Chr12:84832757-84909230 (-)
A/J	MGP_AJ_G0019887	protein coding gene	Chr12:81626579-81697826 (-)
AKR/J	MGP_AKRJ_G0019863	protein coding gene	Chr12:83836006-83907473 (-)
BALB/cJ	MGP_BALBcJ_G0019867	protein coding gene	Chr12:81958015-82029318 (-)
C3H/HeJ	MGP_C3HHeJ_G0019673	protein coding gene	Chr12:84311317-84384151 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020318	protein coding gene	Chr12:87275109-87345824 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017936	protein coding gene	Chr12:78537343-78607508 (-)
CAST/EiJ	MGP_CASTEiJ_G0019222	protein coding gene	Chr12:79247108-79323665 (-)
CBA/J	MGP_CBAJ_G0019644	protein coding gene	Chr12:90642564-90718654 (-)
DBA/2J	MGP_DBA2J_G0019759	protein coding gene	Chr12:81158425-81228638 (-)
FVB/NJ	MGP_FVBNJ_G0019745	protein coding gene	Chr12:80114122-80184517 (-)
LP/J	MGP_LPJ_G0019831	protein coding gene	Chr12:84717740-84788722 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019784	protein coding gene	Chr12:93576907-93648191 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020352	protein coding gene	Chr12:83436679-83506352 (-)
PWK/PhJ	MGP_PWKPhJ_G0018986	protein coding gene	Chr12:75643589-75716315 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018781	protein coding gene	Chr12:77914140-77988293 (-)
WSB/EiJ	MGP_WSBEiJ_G0019274	protein coding gene	Chr12:84104691-84176279 (-)

Human Ortholog

MIDEAS, mitotic deacetylase associated SANT domain protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIDEAS, mitotic deacetylase associated SANT domain protein
Synonyms

c14_5541, C14orf117, C14orf43, ELMSAN1, LSR68
Links

HGNC:19853

NCBI Gene ID: 91748

neXtProt AC: NX_Q6PJG2

UniProt: Q6PJG2
Chr Location

14q24.3; chr14:73715122-73790285 (-) GRCh38

MGI Vertebrate Homology

Mideas stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MIDEAS
Gene Tree

Mideas

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

51
Targeted

2
Genomic Mutations

1 involving Mideas
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects mitosis and hematopoiesis (embryos lack red blood cells) and is embryonic lethal.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

42
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mideas

ZFIN mideasa, mideasb

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All Sequences

50
RefSeq

7
UniProt

4
CCDS

CCDS49109.1

Ensembl

ENSMUSG00000042507 (Evidence)
NCBI Gene

238317

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042507	Ensembl Gene Model \| MGI Sequence Detail	69706	C57BL/6J	± kb
transcript	ENSMUST00000110294	Ensembl \| MGI Sequence Detail	7156	Not Applicable
polypeptide	ENSMUSP00000105923	Ensembl \| MGI Sequence Detail	1089	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR051066 Transcriptional Regulator and Corepressor

IPR013087 Zinc finger C2H2-type

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 6

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MGI:1924593, MGI:6391254

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:291786 Turnbull RE, et al., The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun. 2020 Jun 26;11(1):3252

TSS for Mideas:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116995	Chr12:84265875-84265894 (-)	-230 bp
Tssr116994	Chr12:84265840-84265862 (-)	-196 bp
Tssr116993	Chr12:84265609-84265664 (-)	18 bp
Tssr116992	Chr12:84265586-84265602 (-)	61 bp
Tssr116991	Chr12:84240781-84240841 (-)	24,844 bp
Tssr116990	Chr12:84240761-84240772 (-)	24,888 bp
Tssr116989	Chr12:84240719-84240739 (-)	24,926 bp
Tssr116988	Chr12:84240602-84240636 (-)	25,036 bp
Tssr116987	Chr12:84240544-84240575 (-)	25,095 bp
Tssr116986	Chr12:84240514-84240532 (-)	25,132 bp
Tssr3889	Chr12:84224194-84224219 (-)	41,448 bp
Tssr116985	Chr12:84224145-84224176 (-)	41,494 bp
Tssr116984	Chr12:84222413-84222433 (-)	43,232 bp
Tssr116983	Chr12:84221708-84221717 (-)	43,942 bp
Tssr116982	Chr12:84220225-84220250 (-)	45,417 bp
Tssr116981	Chr12:84219177-84219181 (-)	46,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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