Zdhhc22 MGI Mouse Gene Detail - MGI:2685108 - zinc finger, DHHC-type containing 22

Symbol

Zdhhc22
Name

zinc finger, DHHC-type containing 22
Synonyms

LOC238331

Feature Type

protein coding gene
IDs

MGI:2685108
NCBI Gene: 238331
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:87027537-87037204 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 41.17 cM
Mapping Data

1 experiment

SNPs within 2kb

243 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685108	protein coding gene	Chr12:87027537-87037604 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019975	protein coding gene	Chr12:87864677-87869972 (-)
A/J	MGP_AJ_G0019933	protein coding gene	Chr12:84527109-84532409 (-)
AKR/J	MGP_AKRJ_G0019908	protein coding gene	Chr12:86817595-86822889 (-)
BALB/cJ	MGP_BALBcJ_G0019912	protein coding gene	Chr12:84861536-84867373 (-)
C3H/HeJ	MGP_C3HHeJ_G0019718	protein coding gene	Chr12:87305888-87311182 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020364	protein coding gene	Chr12:90400911-90408257 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017982	protein coding gene	Chr12:81410719-81416063 (-)
CAST/EiJ	MGP_CASTEiJ_G0019268	protein coding gene	Chr12:82319126-82324414 (-)
CBA/J	MGP_CBAJ_G0019690	protein coding gene	Chr12:93881928-93890143 (-)
DBA/2J	MGP_DBA2J_G0019803	protein coding gene	Chr12:84016492-84021795 (-)
FVB/NJ	MGP_FVBNJ_G0019790	protein coding gene	Chr12:83010500-83015798 (-)
LP/J	MGP_LPJ_G0019877	protein coding gene	Chr12:87745387-87750720 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019829	protein coding gene	Chr12:96628266-96633562 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020396	protein coding gene	Chr12:86447953-86453246 (-)
PWK/PhJ	MGP_PWKPhJ_G0019032	protein coding gene	Chr12:78572397-78577729 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018827	protein coding gene	Chr12:80923103-80946722 (-)
WSB/EiJ	MGP_WSBEiJ_G0019321	protein coding gene	Chr12:87193670-87198998 (-)

Human Ortholog

ZDHHC22, zinc finger DHHC-type palmitoyltransferase 22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZDHHC22, zinc finger DHHC-type palmitoyltransferase 22
Synonyms

C14orf59
Links

HGNC:20106

NCBI Gene ID: 283576

neXtProt AC: NX_Q8N966

UniProt: Q8N966
Chr Location

14q24.3; chr14:77131270-77142734 (-) GRCh38

MGI Vertebrate Homology

Zdhhc22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZDHHC22
Gene Tree

Zdhhc22

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Zdhhc22
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN zdhhc22

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All Sequences

35
RefSeq

6
UniProt

2
CCDS

CCDS36500.1

Ensembl

ENSMUSG00000048483 (Evidence)
NCBI Gene

238331

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048483	Ensembl Gene Model \| MGI Sequence Detail	9668	C57BL/6J	± kb
transcript	ENSMUST00000222543	Ensembl \| MGI Sequence Detail	3462	Not Applicable
polypeptide	ENSMUSP00000152660	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030254 palmitoyltransferase ZDHHC22

(term hierarchy)
EC

2.3.1.225
InterPro Domains

IPR001594 Palmitoyltransferase, DHHC domain

IPR000731 Sterol-sensing domain

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All nucleic 5

Genomic 2

cDNA 3

Microarray probesets 2

Summaries

All 26

Gene Ontology 7

Phenotypes 6
Earliest

J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zdhhc22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3904	Chr12:87037433-87037436 (-)	-231 bp
Tssr117154	Chr12:87037377-87037386 (-)	-178 bp
Tssr117153	Chr12:87037343-87037362 (-)	-149 bp
Tssr117152	Chr12:87037296-87037307 (-)	-98 bp
Tssr117151	Chr12:87037277-87037295 (-)	-82 bp
Tssr117150	Chr12:87037258-87037268 (-)	-59 bp
Tssr117149	Chr12:87037242-87037257 (-)	-46 bp
Tssr117148	Chr12:87037225-87037241 (-)	-29 bp
Tssr117147	Chr12:87029862-87029882 (-)	7,332 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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