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Nek10 Gene Detail
Summary
  • Symbol
    Nek10
  • Name
    NIMA (never in mitosis gene a)- related kinase 10
  • Synonyms
    LOC238944
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685128
    NCBI Gene: 674895
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:7457704-7666183 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6900 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685128
 protein coding gene Chr14:7457704-7666348 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021012
 protein coding gene Chr14:7374461-7594654 (+)
A/J MGP_AJ_G0020960
 protein coding gene Chr14:7175954-7368115 (+)
AKR/J MGP_AKRJ_G0020937
 protein coding gene Chr14:7332283-7539968 (+)
BALB/cJ MGP_BALBcJ_G0020963
 protein coding gene Chr14:7216512-7413797 (+)
C3H/HeJ MGP_C3HHeJ_G0020747
 protein coding gene Chr14:7427170-7644126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021396
 protein coding gene Chr14:7563007-7796276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018965
 protein coding gene Chr14:7831531-8033750 (+)
CAST/EiJ MGP_CASTEiJ_G0020270
 protein coding gene Chr14:7338868-7567338 (+)
CBA/J MGP_CBAJ_G0020713
 protein coding gene Chr14:7853205-8129125 (+)
DBA/2J MGP_DBA2J_G0020837
 protein coding gene Chr14:7083714-7300040 (+)
FVB/NJ MGP_FVBNJ_G0020819
 protein coding gene Chr14:7011699-7199612 (+)
LP/J MGP_LPJ_G0020912
 protein coding gene Chr14:7400713-7620299 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020845
 protein coding gene Chr14:7917160-8126215 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021429
 protein coding gene Chr14:7228118-7448513 (+)
PWK/PhJ MGP_PWKPhJ_G0020021
 protein coding gene Chr14:7098500-7328692 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019841
 protein coding gene Chr14:7384422-7813847 (+)
WSB/EiJ MGP_WSBEiJ_G0020327
 protein coding gene Chr14:7264335-7492489 (+)



Homology
more
  • Human Ortholog
    NEK10, NIMA related kinase 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK10, NIMA related kinase 10
  • Synonyms
    CILD44
  • Links
    NCBI Gene ID: 152110
    neXtProt AC: NX_Q6ZWH5
    UniProt: Q6ZWH5

  • Chr Location
    3p24.1
Human Diseases
more
  • Diseases
    1 with human NEK10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    8
  • cDNA Data
    1
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 674895 NCBI Gene Model | MGI Sequence Detail 208480 C57BL/6J ±  kb
transcript NM_001394992 RefSeq | MGI Sequence Detail 8865 C57BL/6  
polypeptide Q3UGM2 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory