Kbtbd7 MGI Mouse Gene Detail - MGI:2685141 - kelch repeat and BTB (POZ) domain containing 7

Symbol

Kbtbd7
Name

kelch repeat and BTB (POZ) domain containing 7
Synonyms

1110008P08Rik, LOC211255

Feature Type

protein coding gene
IDs

MGI:2685141
NCBI Gene: 211255
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:79663951-79668476 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 42.65 cM
Mapping Data

3 experiments

SNPs within 2kb

127 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685141	protein coding gene	Chr14:79663951-79668479 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021597	protein coding gene	Chr14:74550960-74555741 (+)
A/J	MGP_AJ_G0021555	protein coding gene	Chr14:72696470-72700998 (+)
AKR/J	MGP_AKRJ_G0021532	protein coding gene	Chr14:74860427-74867216 (+)
BALB/cJ	MGP_BALBcJ_G0021562	protein coding gene	Chr14:72539657-72543612 (+)
C3H/HeJ	MGP_C3HHeJ_G0021339	protein coding gene	Chr14:74593247-74597221 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022002	protein coding gene	Chr14:77714145-77720166 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019540	protein coding gene	Chr14:70237936-70242453 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0021307	protein coding gene	Chr14:80209495-80216995 (+)
DBA/2J	MGP_DBA2J_G0021432	protein coding gene	Chr14:72097738-72101633 (+)
FVB/NJ	MGP_FVBNJ_G0021408	protein coding gene	Chr14:71444368-71449099 (+)
LP/J	MGP_LPJ_G0021500	protein coding gene	Chr14:75647977-75652578 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021435	protein coding gene	Chr14:78867678-78876743 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022025	protein coding gene	Chr14:74175675-74181427 (+)
PWK/PhJ	MGP_PWKPhJ_G0020599	protein coding gene	Chr14:68892194-68897713 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020436	protein coding gene	Chr14:70149545-70155957 (+)
WSB/EiJ	MGP_WSBEiJ_G0020909	protein coding gene	Chr14:74532626-74538595 (+)

Human Ortholog

KBTBD7, kelch repeat and BTB domain containing 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KBTBD7, kelch repeat and BTB domain containing 7
Links

HGNC:25266

NCBI Gene ID: 84078

neXtProt AC: NX_Q8WVZ9

UniProt: Q8WVZ9
Chr Location

13q14.11; chr13:41189834-41194569 (-) GRCh38

MGI Vertebrate Homology

Kbtbd7 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: KBTBD7
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Kbtbd7

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Targeted

2
Genomic Mutations

1 involving Kbtbd7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

1
cDNA Data

51
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kbtbd7

ZFIN kbtbd7

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS27298.1

Ensembl

ENSMUSG00000043881 (Evidence)
NCBI Gene

211255

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043881	Ensembl Gene Model \| MGI Sequence Detail	4526	C57BL/6J	± kb
transcript	ENSMUST00000061222	Ensembl \| MGI Sequence Detail	4526	Not Applicable
polypeptide	ENSMUSP00000060768	Ensembl \| MGI Sequence Detail	690	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR047931 KBTBD6/KBTBD7, BACK domain

IPR047933 KBTBD6/KBTBD7, BTB/POZ domain

IPR046790 KBTB, W-type LIR motif

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily
GlyGen

G5E8C2 1 site, 1 N-linked glycan (1 site)

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All nucleic 51

cDNA 51

Microarray probesets 4

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MGI:1922023, MGI:2145762

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kbtbd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126788	Chr14:79663850-79663893 (+)	-79 bp
Tssr126789	Chr14:79663894-79663918 (+)	-45 bp
Tssr126790	Chr14:79664031-79664043 (+)	86 bp
Tssr126791	Chr14:79664057-79664093 (+)	124 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24