Olfm4 MGI Mouse Gene Detail - MGI:2685142

Symbol

Olfm4
Name

olfactomedin 4
Synonyms

GC1, GW112, LOC239192, LOC380924, OlfD, pPD4

Feature Type

protein coding gene
IDs

MGI:2685142
NCBI Gene: 380924
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:80237742-80260581 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 42.78 cM
Mapping Data

1 experiment

SNPs within 2kb

488 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685142	protein coding gene	Chr14:80221521-80260581 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021605	protein coding gene	Chr14:75172397-75195348 (+)
A/J	MGP_AJ_G0021563	protein coding gene	Chr14:73277925-73299681 (+)
AKR/J	MGP_AKRJ_G0021539	protein coding gene	Chr14:75458014-75481142 (+)
BALB/cJ	MGP_BALBcJ_G0021569	protein coding gene	Chr14:73133257-73154995 (+)
C3H/HeJ	MGP_C3HHeJ_G0021347	protein coding gene	Chr14:75194926-75216583 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022009	protein coding gene	Chr14:78338695-78361451 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019548	protein coding gene	Chr14:70791558-70813326 (+)
CAST/EiJ	MGP_CASTEiJ_G0020862	protein coding gene	Chr14:71975998-71999746 (+)
CBA/J	MGP_CBAJ_G0021315	protein coding gene	Chr14:80850667-80875387 (+)
DBA/2J	MGP_DBA2J_G0021439	protein coding gene	Chr14:72674563-72696306 (+)
FVB/NJ	MGP_FVBNJ_G0021415	protein coding gene	Chr14:72014200-72035790 (+)
LP/J	MGP_LPJ_G0021507	protein coding gene	Chr14:76255709-76277306 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021443	protein coding gene	Chr14:79498537-79521000 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022032	protein coding gene	Chr14:74761588-74784011 (+)
PWK/PhJ	MGP_PWKPhJ_G0020607	protein coding gene	Chr14:69474928-69496908 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020443	protein coding gene	Chr14:70722256-70744243 (+)
WSB/EiJ	MGP_WSBEiJ_G0020917	protein coding gene	Chr14:75139063-75161378 (+)

Human Ortholog

OLFM4, olfactomedin 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OLFM4, olfactomedin 4
Synonyms

bA209J19.1, GC1, GW112, hGC-1, hOLfD, OlfD, OLM4, pDP4, UNQ362
Links

HGNC:17190

NCBI Gene ID: 10562

neXtProt AC: NX_Q6UX06

UniProt: Q6UX06
Chr Location

13q14.3; chr13:53028813-53052057 (+) GRCh38

MGI Vertebrate Homology

Olfm4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OLFM4
Gene Tree

Olfm4

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Olfm4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced colonization of the gastric mucosa by Helicobacter pylori but increased inflammatory response to H. pylori infection.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

17
cDNA Data

12
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA OLFM4

Xenbase olfm4

ZFIN olfm4.2

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All Sequences

39
RefSeq

4
UniProt

4
CCDS

CCDS36989.2

Ensembl

ENSMUSG00000022026 (Evidence)
NCBI Gene

380924

			Length	Strain/Species	Flank
genomic	380924	NCBI Gene Model \| MGI Sequence Detail	22840	C57BL/6J	± kb
transcript	NM_001351947	RefSeq \| MGI Sequence Detail	2768	C57BL/6
polypeptide	Q3UZZ4	UniProt \| EBI \| MGI Sequence Detail	505	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011626 olfactomedin-4

(term hierarchy)
InterPro Domains

IPR003112 Olfactomedin-like domain

IPR050605 Olfactomedin-like domain-containing protein
GlyGen

Q3UZZ4 2 sites

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 3

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MGI:2685759

Summaries

All 70

Developmental Gene Expression 18

Gene Ontology 6

Phenotypes 22
Earliest

J:90964 Rosenbauer F, et al., pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Blood. 2004 Jun 1;103(11):4294-301
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Olfm4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126831	Chr14:80237732-80237749 (+)	-1 bp
Tssr126832	Chr14:80243658-80243690 (+)	5,932 bp
Tssr126833	Chr14:80243707-80243716 (+)	5,970 bp
Tssr126834	Chr14:80258649-80258657 (+)	20,911 bp
Tssr126835	Chr14:80258720-80258731 (+)	20,984 bp
Tssr126836	Chr14:80258862-80258870 (+)	21,124 bp
Tssr126837	Chr14:80259600-80259620 (+)	21,868 bp
Tssr126838	Chr14:80259671-80259680 (+)	21,934 bp
Tssr126839	Chr14:80259764-80259779 (+)	22,030 bp
Tssr126840	Chr14:80260000-80260007 (+)	22,262 bp
Tssr126841	Chr14:80260149-80260158 (+)	22,412 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24