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Zfp407 Gene Detail
Summary
  • Symbol
    Zfp407
  • Name
    zinc finger protein 407
  • Synonyms
    6430585N13Rik, LOC240469, LOC381139
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685179
    NCBI Gene: 240476
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84225826-84612815 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685179
 protein coding gene Chr18:84146152-84612815 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024606
 protein coding gene Chr18:85267140-85757300 (-)
A/J MGP_AJ_G0024573
 protein coding gene Chr18:81515372-81985062 (-)
AKR/J MGP_AKRJ_G0024544
 protein coding gene Chr18:83938337-84413777 (-)
BALB/cJ MGP_BALBcJ_G0024571
 protein coding gene Chr18:81706245-82177109 (-)
C3H/HeJ MGP_C3HHeJ_G0024340
 protein coding gene Chr18:84060415-84530107 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025018
 protein coding gene Chr18:87386052-87883692 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022449
 protein coding gene Chr18:80225657-80681926 (-)
CAST/EiJ MGP_CASTEiJ_G0023813
 protein coding gene Chr18:84402034-84894653 (-)
CBA/J MGP_CBAJ_G0024310
 protein coding gene Chr18:90519777-91036366 (-)
DBA/2J MGP_DBA2J_G0024440
 protein coding gene Chr18:81036163-81501348 (-)
FVB/NJ MGP_FVBNJ_G0024406
 protein coding gene Chr18:80362412-80831544 (-)
LP/J MGP_LPJ_G0024524
 protein coding gene Chr18:85070998-85551814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024436
 protein coding gene Chr18:91755348-92270237 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025067
 protein coding gene Chr18:84133541-84626954 (-)
PWK/PhJ MGP_PWKPhJ_G0023558
 protein coding gene Chr18:81425966-81893792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023364
 protein coding gene Chr18:84181211-84664995 (-)
WSB/EiJ MGP_WSBEiJ_G0023875
 protein coding gene Chr18:84104108-84588370 (-)



Homology
more
  • Human Ortholog
    ZNF407, zinc finger protein 407
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF407, zinc finger protein 407
  • Synonyms
    SIMHA
  • Links
    NCBI Gene ID: 55628
    neXtProt AC: NX_Q9C0G0
    UniProt: Q9C0G0

  • Chr Location
    18q22.3; chr18:74597870-75065671 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure of blastocyst formation and complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and show no further development after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    107
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240476 NCBI Gene Model | MGI Sequence Detail 386990 C57BL/6J ±  kb
transcript NM_001033341 RefSeq | MGI Sequence Detail 7909 C57BL/6  
polypeptide NP_001028513 RefSeq | MGI Sequence Detail 2246 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR003604 Matrin/U1-C-like, C2H2-type zinc finger
    IPR050331 Zinc finger
    IPR050688 Zinc finger and ubiquitin peptidase domain-containing protein
    IPR036236 Zinc finger C2H2 superfamily
    IPR013087 Zinc finger C2H2-type
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 23
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685180, MGI:2685794
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory