Dusp5 MGI Mouse Gene Detail - MGI:2685183 - dual specificity phosphatase 5

Symbol

Dusp5
Name

dual specificity phosphatase 5
Synonyms

LOC240672

Feature Type

protein coding gene
IDs

MGI:2685183
NCBI Gene: 240672
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:53517576-53530240 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 47.98 cM
Mapping Data

1 experiment

SNPs within 2kb

354 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685183	protein coding gene	Chr19:53517540-53530862 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025247	protein coding gene	Chr19:53681735-53694761 (+)
A/J	MGP_AJ_G0025223	protein coding gene	Chr19:51033018-51046257 (+)
AKR/J	MGP_AKRJ_G0025192	protein coding gene	Chr19:52631191-52646547 (+)
BALB/cJ	MGP_BALBcJ_G0025218	protein coding gene	Chr19:51117412-51131014 (+)
C3H/HeJ	MGP_C3HHeJ_G0024978	protein coding gene	Chr19:52856834-52870173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025661	protein coding gene	Chr19:54972444-54988696 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023073	protein coding gene	Chr19:50028450-50041444 (+)
CAST/EiJ	MGP_CASTEiJ_G0024443	protein coding gene	Chr19:52821696-52836515 (+)
CBA/J	MGP_CBAJ_G0024958	protein coding gene	Chr19:57703256-57716448 (+)
DBA/2J	MGP_DBA2J_G0025090	protein coding gene	Chr19:50845494-50858587 (+)
FVB/NJ	MGP_FVBNJ_G0025051	protein coding gene	Chr19:50545248-50558266 (+)
LP/J	MGP_LPJ_G0025176	protein coding gene	Chr19:53544564-53558974 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025084	protein coding gene	Chr19:57156684-57170020 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025719	protein coding gene	Chr19:52830502-52843603 (+)
PWK/PhJ	MGP_PWKPhJ_G0024191	protein coding gene	Chr19:50750659-50764026 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023994	protein coding gene	Chr19:51504870-51517852 (+)
WSB/EiJ	MGP_WSBEiJ_G0024513	protein coding gene	Chr19:52967652-52980822 (+)

Human Ortholog

DUSP5, dual specificity phosphatase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP5, dual specificity phosphatase 5
Synonyms

DUSP, HVH3
Links

HGNC:3071

NCBI Gene ID: 1847

neXtProt AC: NX_Q16690

UniProt: Q16690
Chr Location

10q25.2; chr10:110497907-110511533 (+) GRCh38

MGI Vertebrate Homology

Dusp5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP5
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp5

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Phenotype Summary

10 phenotypes from 4 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Targeted

8
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele exhibit increased proliferation and apoptosis and altered metabolic profiles in T cells. Mice homozygous for other null alleles exhibit altered eosinophilic response to parasicitc infection and increased susceptibility to induced tumors.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

16
cDNA Data

5
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp5

ZFIN dusp5

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS38024.1

Ensembl

ENSMUSG00000034765 (Evidence)
NCBI Gene

240672

			Length	Strain/Species	Flank
genomic	240672	NCBI Gene Model \| MGI Sequence Detail	12665	C57BL/6J	± kb
transcript	NM_001085390	RefSeq \| MGI Sequence Detail	1815	C57BL/6
polypeptide	NP_001078859	RefSeq \| MGI Sequence Detail	384	C57BL/6

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UniProt

1 Sequence
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 13
Earliest

J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dusp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156985	Chr19:53517531-53517536 (+)	-42 bp
Tssr156986	Chr19:53517568-53517582 (+)	-1 bp
Tssr156987	Chr19:53522241-53522252 (+)	4,671 bp
Tssr156988	Chr19:53522255-53522270 (+)	4,687 bp
Tssr156989	Chr19:53522332-53522343 (+)	4,762 bp
Tssr156990	Chr19:53522357-53522373 (+)	4,789 bp
Tssr156991	Chr19:53525891-53525910 (+)	8,325 bp
Tssr156992	Chr19:53525921-53525937 (+)	8,353 bp
Tssr156993	Chr19:53525946-53525962 (+)	8,378 bp
Tssr156994	Chr19:53526105-53526111 (+)	8,532 bp
Tssr156995	Chr19:53527804-53527822 (+)	10,237 bp
Tssr156996	Chr19:53527938-53527951 (+)	10,369 bp
Tssr156997	Chr19:53528051-53528069 (+)	10,484 bp
Tssr156998	Chr19:53528134-53528149 (+)	10,566 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24