Lcor MGI Mouse Gene Detail - MGI:2443930 - ligand dependent nuclear receptor corepressor

Symbol

Lcor
Name

ligand dependent nuclear receptor corepressor
Synonyms

3110023F06Rik, A630025C20Rik, Gm340, LOC381224, mKIAA1795, Mlr2

Feature Type

protein coding gene
IDs

MGI:2443930
NCBI Gene: 212391
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:41471076-41574975 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 34.97 cM
Mapping Data

2 experiments

SNPs within 2kb

1841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443930	protein coding gene	Chr19:41471076-41584600 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025123	protein coding gene	Chr19:40745002-40835602 (+)
A/J	MGP_AJ_G0025100	protein coding gene	Chr19:38790020-38869926 (+)
AKR/J	MGP_AKRJ_G0025068	protein coding gene	Chr19:40071700-40157736 (+)
BALB/cJ	MGP_BALBcJ_G0025094	protein coding gene	Chr19:38849867-38934799 (+)
C3H/HeJ	MGP_C3HHeJ_G0024854	protein coding gene	Chr19:40213834-40294541 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025538	protein coding gene	Chr19:41836378-41920270 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022951	protein coding gene	Chr19:38158683-38234490 (+)
CAST/EiJ	MGP_CASTEiJ_G0024319	protein coding gene	Chr19:39879208-39962452 (+)
CBA/J	MGP_CBAJ_G0024834	protein coding gene	Chr19:43863830-43951862 (+)
DBA/2J	MGP_DBA2J_G0024966	protein coding gene	Chr19:38645546-38726224 (+)
FVB/NJ	MGP_FVBNJ_G0024927	protein coding gene	Chr19:38411654-38491429 (+)
LP/J	MGP_LPJ_G0025052	protein coding gene	Chr19:40753947-40837630 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024958	protein coding gene	Chr19:43513656-43598715 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025595	protein coding gene	Chr19:40112405-40194408 (+)
PWK/PhJ	MGP_PWKPhJ_G0024069	protein coding gene	Chr19:38515831-38597988 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023872	protein coding gene	Chr19:38840867-38926807 (+)
WSB/EiJ	MGP_WSBEiJ_G0024389	protein coding gene	Chr19:40263187-40346057 (+)

Human Ortholog

LCOR, ligand dependent nuclear receptor corepressor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LCOR, ligand dependent nuclear receptor corepressor
Synonyms

C10orf12, MLR2
Links

HGNC:29503

NCBI Gene ID: 84458

neXtProt AC: NX_Q96JN0

UniProt: Q96JN0
Chr Location

10q24.1; chr10:96832254-96995956 (+) GRCh38

MGI Vertebrate Homology

Lcor stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: LCOR
Gene Tree

Lcor

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

147
Endonuclease-mediated

2
Gene trapped

139
Targeted

6
Incidental Mutations

Mutagenetix , APF , APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a knock-out allele die between E11.5 and birth.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

961
Tissues

136
cDNA Data

24
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lcor

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All Sequences

63
RefSeq

5
UniProt

6
CCDS

CCDS29810.1, CCDS89392.1

Ensembl

ENSMUSG00000025019 (Evidence)
NCBI Gene

212391

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025019	Ensembl Gene Model \| MGI Sequence Detail	103900	C57BL/6J	± kb
transcript	ENSMUST00000238398	Ensembl \| MGI Sequence Detail	5764	Not Applicable
polypeptide	ENSMUSP00000158715	Ensembl \| MGI Sequence Detail	1696	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009730 ligand-dependent corepressor

(term hierarchy)
InterPro Domains

IPR007889 DNA binding HTH domain, Psq-type

IPR009057 Homeobox-like domain superfamily

IPR028104 Protein of unknown function DUF4553
GlyGen

Q6ZPI3 1 site, 1 O-linked glycan (1 site)

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All nucleic 27

cDNA 24

Primer pair 2

Other 1

Microarray probesets 5

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MGI:1920403, MGI:2685186

Summaries

All 52

Developmental Gene Expression 13

Gene Ontology 7

Phenotypes 14
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84

TSS for Lcor:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156427	Chr19:41471071-41471127 (+)	23 bp
Tssr156428	Chr19:41471395-41471443 (+)	343 bp
Tssr156429	Chr19:41471540-41471583 (+)	486 bp
Tssr156430	Chr19:41471642-41471660 (+)	575 bp
Tssr156431	Chr19:41483552-41483554 (+)	12,477 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24