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Tm9sf5 Gene Detail
Summary
  • Symbol
    Tm9sf5
  • Name
    transmembrane 9 superfamily member 5
  • Synonyms
    Gm364, LOC245423
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685210
    NCBI Gene: 245423
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:56454514-56534127 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 31.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1938 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685210
 protein coding gene ChrX:56446127-56534133 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035749
 protein coding gene ChrX:52743400-52831343 (+)
A/J MGP_AJ_G0035732
 protein coding gene ChrX:52940683-53017614 (+)
AKR/J MGP_AKRJ_G0035652
 protein coding gene ChrX:54337936-54422706 (+)
BALB/cJ MGP_BALBcJ_G0035719
 protein coding gene ChrX:52379221-52460917 (+)
C3H/HeJ MGP_C3HHeJ_G0035421
 protein coding gene ChrX:53276512-53352124 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036248
 protein coding gene ChrX:54130948-54214541 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033099
 protein coding gene ChrX:52335869-52406982 (+)
CAST/EiJ MGP_CASTEiJ_G0034714
 protein coding gene ChrX:39167943-39246240 (+)
CBA/J MGP_CBAJ_G0035396
 protein coding gene ChrX:55717916-55811458 (+)
DBA/2J MGP_DBA2J_G0035550
 protein coding gene ChrX:52508120-52592031 (+)
FVB/NJ MGP_FVBNJ_G0035500
 protein coding gene ChrX:52109109-52192257 (+)
LP/J MGP_LPJ_G0035638
 protein coding gene ChrX:53322935-53405621 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035536
 protein coding gene ChrX:57261674-57348227 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036264
 protein coding gene ChrX:52765815-52844730 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034254
 protein coding gene ChrX:39918891-39995939 (+)
WSB/EiJ MGP_WSBEiJ_G0034857
 protein coding gene ChrX:52311936-52391719 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced female fertility, decreased numbers of primordial and growing ovarian follicles, and impaired oocyte quality associated with oxidative stress, decreased mitochondrial membrane potential, decreased oocyte maturation, and increased aneuploidy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079584 Ensembl Gene Model | MGI Sequence Detail 79614 C57BL/6J ±  kb
    transcript ENSMUST00000114725 Ensembl | MGI Sequence Detail 2156 Not Applicable  
    polypeptide ENSMUSP00000110373 Ensembl | MGI Sequence Detail 671 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR004240 Nonaspanin (TM9SF)
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6466987
    References
    more
    • Summaries
      All 13
      Gene Ontology 2
      Phenotypes 1
    • Earliest
      J:320690 Chen LJ, et al., Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation. Cell Death Differ. 2022 Feb;29(2):366-380
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory