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Pm20d2 Gene Detail
Summary
  • Symbol
    Pm20d2
  • Name
    peptidase M20 domain containing 2
  • Synonyms
    Acy1l2, LOC242377
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685270
    NCBI Gene: 242377
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33174230-33189737 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    585 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685270
 protein coding gene Chr4:33170309-33189737 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028120
 protein coding gene Chr4:30679257-30696403 (-)
A/J MGP_AJ_G0028078
 protein coding gene Chr4:29582211-29597728 (-)
AKR/J MGP_AKRJ_G0028041
 protein coding gene Chr4:30353020-30370277 (-)
BALB/cJ MGP_BALBcJ_G0028089
 protein coding gene Chr4:29840123-29855602 (-)
C3H/HeJ MGP_C3HHeJ_G0027818
 protein coding gene Chr4:30650484-30665978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028531
 protein coding gene Chr4:31884341-31901254 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025872
 protein coding gene Chr4:27640364-27655747 (-)
CAST/EiJ MGP_CASTEiJ_G0027273
 protein coding gene Chr4:30426152-30441510 (-)
CBA/J MGP_CBAJ_G0027790
 protein coding gene Chr4:32908606-32924039 (-)
DBA/2J MGP_DBA2J_G0027934
 protein coding gene Chr4:29581995-29597493 (-)
FVB/NJ MGP_FVBNJ_G0027900
 protein coding gene Chr4:29014352-29030049 (-)
LP/J MGP_LPJ_G0028042
 protein coding gene Chr4:30766991-30782864 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027933
 protein coding gene Chr4:35491926-35507323 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028590
 protein coding gene Chr4:30362110-30378349 (-)
PWK/PhJ MGP_PWKPhJ_G0026992
 protein coding gene Chr4:29587055-29602375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026821
 protein coding gene Chr4:30249594-30265683 (-)
WSB/EiJ MGP_WSBEiJ_G0027349
 protein coding gene Chr4:30365462-30381740 (-)



Homology
more
  • Human Ortholog
    PM20D2, peptidase M20 domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PM20D2, peptidase M20 domain containing 2
  • Synonyms
    ACY1L2
  • Links
    NCBI Gene ID: 135293
    neXtProt AC: NX_Q8IYS1
    UniProt: Q8IYS1

  • Chr Location
    6q15; chr6:89093940-89165565 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054659 Ensembl Gene Model | MGI Sequence Detail 15508 C57BL/6J ±  kb
transcript ENSMUST00000098181 Ensembl | MGI Sequence Detail 1445 Not Applicable  
polypeptide ENSMUSP00000095783 Ensembl | MGI Sequence Detail 431 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4
References
more
  • Summaries
    All 22
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:216013 Veiga-da-Cunha M, et al., Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as beta-alanyl-lysine dipeptidase. J Biol Chem. 2014 Jul 11;289(28):19726-36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory