Garem2 MGI Mouse Gene Detail - MGI:2685290 - GRB2 associated regulator of MAPK1 subtype 2

Symbol

Garem2
Name

GRB2 associated regulator of MAPK1 subtype 2
Synonyms

Fam59b, Gareml, LOC242915

Feature Type

protein coding gene
IDs

MGI:2685290
NCBI Gene: 242915
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:30310194-30323378 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.92 cM
Mapping Data

1 experiment

SNPs within 2kb

363 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685290	protein coding gene	Chr5:30310159-30323378 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029383	protein coding gene	Chr5:28088732-28101868 (+)
A/J	MGP_AJ_G0029349	protein coding gene	Chr5:27149796-27163053 (+)
AKR/J	MGP_AKRJ_G0029300	protein coding gene	Chr5:28234663-28247799 (+)
BALB/cJ	MGP_BALBcJ_G0029360	protein coding gene	Chr5:27679548-27692809 (+)
C3H/HeJ	MGP_C3HHeJ_G0029081	protein coding gene	Chr5:28264871-28278112 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029813	protein coding gene	Chr5:29805433-29818679 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027051	protein coding gene	Chr5:24670763-24683973 (+)
CAST/EiJ	MGP_CASTEiJ_G0028492	protein coding gene	Chr5:27368448-27381642 (+)
CBA/J	MGP_CBAJ_G0029049	protein coding gene	Chr5:30356448-30369703 (+)
DBA/2J	MGP_DBA2J_G0029198	protein coding gene	Chr5:27355077-27368340 (+)
FVB/NJ	MGP_FVBNJ_G0029156	protein coding gene	Chr5:26756122-26770782 (+)
LP/J	MGP_LPJ_G0029283	protein coding gene	Chr5:28535898-28549034 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029185	protein coding gene	Chr5:31306878-31320102 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029847	protein coding gene	Chr5:27797974-27812198 (+)
PWK/PhJ	MGP_PWKPhJ_G0028216	protein coding gene	Chr5:26464741-26478079 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028047	protein coding gene	Chr5:27142222-27155471 (+)
WSB/EiJ	MGP_WSBEiJ_G0028572	protein coding gene	Chr5:27874775-27888885 (+)

Human Ortholog

GAREM2, GRB2 associated regulator of MAPK1 subtype 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAREM2, GRB2 associated regulator of MAPK1 subtype 2
Synonyms

FAM59B, GAREML
Links

HGNC:27172

NCBI Gene ID: 150946

neXtProt AC: NX_Q75VX8

UniProt: Q75VX8
Chr Location

2p23.3; chr2:26173088-26204304 (+) GRCh38

MGI Vertebrate Homology

Garem2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GAREM2
Gene Tree

Garem2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Radiation induced

3
Spontaneous

1
Targeted

4
Genomic Mutations

6 involving Garem2
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

5
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase garem2

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS51449.1

Ensembl

ENSMUSG00000044576 (Evidence)
NCBI Gene

242915

			Length	Strain/Species	Flank
genomic	242915	NCBI Gene Model \| MGI Sequence Detail	13185	C57BL/6J	± kb
transcript	NM_001167879	RefSeq \| MGI Sequence Detail	3832	C57BL/6
polypeptide	Q6PAJ3	UniProt \| EBI \| MGI Sequence Detail	880	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032679 GRB2-associated and regulator of MAPK protein 2

(term hierarchy)
InterPro Domains

IPR025946 CABIT domain

IPR052281 GRB2-associated and regulator of MAPK

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 41

Diseases 1

Gene Ontology 1

Phenotypes 23
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:287781 Nishino T, et al., Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain. Mol Brain. 2019 Nov 12;12(1):94

TSS for Garem2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45570	Chr5:30310175-30310217 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24