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Ffar3 Gene Detail
Summary
  • Symbol
    Ffar3
  • Name
    free fatty acid receptor 3
  • Synonyms
    Gpr41, LOC233080
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685324
    NCBI Gene: 233080
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30553755-30555603 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685324
 protein coding gene Chr7:30553755-30555603 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032047
 protein coding gene Chr7:29885583-29887431 (-)
A/J MGP_AJ_G0032024
 protein coding gene Chr7:29063236-29065080 (-)
AKR/J MGP_AKRJ_G0031957
 protein coding gene Chr7:29807224-29809072 (-)
BALB/cJ MGP_BALBcJ_G0032031
 protein coding gene Chr7:29252556-29254400 (-)
C3H/HeJ MGP_C3HHeJ_G0031750
 protein coding gene Chr7:30268986-30270834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032497
 protein coding gene Chr7:30866657-30868505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029547
 protein coding gene Chr7:30073695-30075533 (-)
CAST/EiJ MGP_CASTEiJ_G0031084
 protein coding gene Chr7:23533380-23535222 (-)
CBA/J MGP_CBAJ_G0031716
 protein coding gene Chr7:32339207-32341055 (-)
DBA/2J MGP_DBA2J_G0031868
 protein coding gene Chr7:28807181-28809030 (-)
FVB/NJ MGP_FVBNJ_G0031825
 protein coding gene Chr7:28921244-28923092 (-)
LP/J MGP_LPJ_G0031949
 protein coding gene Chr7:30202700-30204548 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031861
 protein coding gene Chr7:31570620-31572464 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032525
 protein coding gene Chr7:29315795-29317644 (-)
PWK/PhJ MGP_PWKPhJ_G0030808
 protein coding gene Chr7:23828064-23829913 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030643
 protein coding gene Chr7:20323411-20325254 (-)
WSB/EiJ MGP_WSBEiJ_G0031194
 protein coding gene Chr7:29722594-29724442 (-)



Homology
more
  • Human Ortholog
    FFAR3, free fatty acid receptor 3
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FFAR3, free fatty acid receptor 3
  • Synonyms
    FFA3R, GPR41, GPR42
  • Links
    NCBI Gene ID: 2865
    neXtProt AC: NX_O14843
    UniProt: O14843

  • Chr Location
    19q13.12; chr19:35358151-35360489 (+)  GRCh38
  • Human Ortholog
    GPR42, G protein-coupled receptor 42
  • Synonyms
    FFAR1L, FFAR3L, GPR41L, GPR42P
  • Links
    NCBI Gene ID: 2866
    neXtProt AC: NX_O15529
    UniProt: O15529

  • Chr Location
    19q13.12; chr19:35371068-35372962 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 6 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    1 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele colonized with a model fermentative community are lean and exhibit decreased weight gain, increased intestinal transit rate, and reduced caloric extraction. Mice homozygous for a knock-out allele exhibit a slight increase in serum insulin when fed a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    20
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233080 NCBI Gene Model | MGI Sequence Detail 1849 C57BL/6J ±  kb
    transcript NM_001033316 RefSeq | MGI Sequence Detail 1625 C57BL/6  
    polypeptide Q3UFD7 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 3
      Primer pair 1
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 34
    • Earliest
      J:210926 Xiong Y, et al., Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50
    • Latest
      J:347030 Mishra SP, et al., Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function. JCI Insight. 2024 Feb 8;9(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory