Ntn5 MGI Mouse Gene Detail - MGI:2685330

Symbol

Ntn5
Name

netrin 5
Synonyms

LOC243967

Feature Type

protein coding gene
IDs

MGI:2685330
NCBI Gene: 243967
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:45333519-45343980 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.43 cM
Mapping Data

1 experiment

SNPs within 2kb

294 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685330	protein coding gene	Chr7:45333446-45343980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032239	protein coding gene	Chr7:45988346-45998926 (+)
A/J	MGP_AJ_G0032218	protein coding gene	Chr7:45079907-45090537 (+)
AKR/J	MGP_AKRJ_G0032154	protein coding gene	Chr7:46327070-46337604 (+)
BALB/cJ	MGP_BALBcJ_G0032230	protein coding gene	Chr7:45073314-45083944 (+)
C3H/HeJ	MGP_C3HHeJ_G0031945	protein coding gene	Chr7:46824397-46835461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032722	protein coding gene	Chr7:48240566-48251100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029736	protein coding gene	Chr7:47634903-47645404 (+)
CAST/EiJ	MGP_CASTEiJ_G0031274	protein coding gene	Chr7:38262765-38273335 (+)
CBA/J	MGP_CBAJ_G0031910	protein coding gene	Chr7:49846635-49857169 (+)
DBA/2J	MGP_DBA2J_G0032068	protein coding gene	Chr7:44757517-44768097 (+)
FVB/NJ	MGP_FVBNJ_G0032019	protein coding gene	Chr7:44532556-44543090 (+)
LP/J	MGP_LPJ_G0032146	protein coding gene	Chr7:46695154-46705664 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032056	protein coding gene	Chr7:48531021-48541555 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032738	protein coding gene	Chr7:45542143-45552773 (+)
PWK/PhJ	MGP_PWKPhJ_G0030996	protein coding gene	Chr7:38125911-38136514 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030834	protein coding gene	Chr7:33568002-33578503 (+)
WSB/EiJ	MGP_WSBEiJ_G0031391	protein coding gene	Chr7:46047286-46057817 (+)

Human Ortholog

NTN5, netrin 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NTN5, netrin 5
Links

HGNC:25208

NCBI Gene ID: 126147

neXtProt AC: NX_Q8WTR8

UniProt: Q8WTR8
Chr Location

19q13.33; chr19:48661407-48673081 (-) GRCh38

MGI Vertebrate Homology

Ntn5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NTN5
Gene Tree

Ntn5

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele exhibit ectopic motor neurons that migrate out of the ventral horn and into the motor roots.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

14
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

65
RefSeq

28
UniProt

4
CCDS

CCDS39957.1, CCDS71964.1, CCDS80723.1

Ensembl

ENSMUSG00000070564 (Evidence)
NCBI Gene

243967

			Length	Strain/Species	Flank
genomic	243967	NCBI Gene Model \| MGI Sequence Detail	10462	C57BL/6J	± kb
transcript	NM_001358870	RefSeq \| MGI Sequence Detail	1802	C57BL/6
polypeptide	Q3UQ22	UniProt \| EBI \| MGI Sequence Detail	452	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011466 netrin-5

(term hierarchy)
InterPro Domains

IPR050440 Laminin/Netrin Extracellular Matrix

IPR002049 Laminin-type EGF domain

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
GlyGen

Q3UQ22 1 site, 1 N-linked glycan (1 site)

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All nucleic 7

cDNA 3

Primer pair 2

Other 2

Microarray probesets 2

Summaries

All 21

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 4
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)

TSS for Ntn5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66606	Chr7:45333793-45333817 (+)	286 bp
Tssr66607	Chr7:45333822-45333845 (+)	315 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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