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Usp35 Gene Detail
Summary
  • Symbol
    Usp35
  • Name
    ubiquitin specific peptidase 35
  • Synonyms
    LOC244144, LOC381901
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685339
    NCBI Gene: 244144
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:96958587-96981227 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    626 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685339
 protein coding gene Chr7:96958587-96981502 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032520
 protein coding gene Chr7:99989270-100013068 (-)
A/J MGP_AJ_G0032494
 protein coding gene Chr7:97511460-97534505 (-)
AKR/J MGP_AKRJ_G0032430
 protein coding gene Chr7:99824918-99847118 (-)
BALB/cJ MGP_BALBcJ_G0032505
 protein coding gene Chr7:97205358-97227976 (-)
C3H/HeJ MGP_C3HHeJ_G0032220
 protein coding gene Chr7:100193090-100215190 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033003
 protein coding gene Chr7:103885196-103908834 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029998
 protein coding gene Chr7:99974957-99997427 (-)
CAST/EiJ MGP_CASTEiJ_G0031547
 protein coding gene Chr7:91701057-91726530 (-)
CBA/J MGP_CBAJ_G0032187
 protein coding gene Chr7:107395880-107421319 (-)
DBA/2J MGP_DBA2J_G0032339
 protein coding gene Chr7:95880322-95902876 (-)
FVB/NJ MGP_FVBNJ_G0032295
 protein coding gene Chr7:95658126-95681950 (-)
LP/J MGP_LPJ_G0032428
 protein coding gene Chr7:101315460-101337686 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032328
 protein coding gene Chr7:108940331-108963941 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033025
 protein coding gene Chr7:99127827-99151330 (-)
PWK/PhJ MGP_PWKPhJ_G0031265
 protein coding gene Chr7:88932668-88956935 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031108
 protein coding gene Chr7:86361511-86386370 (-)
WSB/EiJ MGP_WSBEiJ_G0031664
 protein coding gene Chr7:99764624-99787408 (-)



Homology
more
  • Human Ortholog
    USP35, ubiquitin specific peptidase 35
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP35, ubiquitin specific peptidase 35
  • Links
    NCBI Gene ID: 57558
    neXtProt AC: NX_Q9P2H5
    UniProt: Q9P2H5

  • Chr Location
    11q14.1; chr11:78188812-78237219 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035713 Ensembl Gene Model | MGI Sequence Detail 22641 C57BL/6J ±  kb
transcript ENSMUST00000139582 Ensembl | MGI Sequence Detail 4262 Not Applicable  
polypeptide ENSMUSP00000137726 Ensembl | MGI Sequence Detail 1009 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.4.19.12
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR049407 Ubiquitin carboxyl-terminal hydrolase 38-like, N-terminal domain
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
  • GlyGen
    M0QWN7 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685934
References
more
  • Summaries
    All 44
    Gene Ontology 2
    Phenotypes 29
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory