Tnfaip8l3 MGI Mouse Gene Detail - MGI:2685363 - tumor necrosis factor, alpha-induced protein 8-like 3

Symbol

Tnfaip8l3
Name

tumor necrosis factor, alpha-induced protein 8-like 3
Synonyms

9930029P06Rik, LOC244882

Feature Type

protein coding gene
IDs

MGI:2685363
NCBI Gene: 244882
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:53932890-53975695 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.46 cM
Mapping Data

1 experiment

SNPs within 2kb

1257 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685363	protein coding gene	Chr9:53930689-53975695 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034820	protein coding gene	Chr9:53057570-53097565 (-)
A/J	MGP_AJ_G0034801	protein coding gene	Chr9:51381247-51421342 (-)
AKR/J	MGP_AKRJ_G0034729	protein coding gene	Chr9:52521780-52561499 (-)
BALB/cJ	MGP_BALBcJ_G0034793	protein coding gene	Chr9:51141914-51182041 (-)
C3H/HeJ	MGP_C3HHeJ_G0034503	protein coding gene	Chr9:52996104-53040518 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035312	protein coding gene	Chr9:54568040-54608724 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032224	protein coding gene	Chr9:50778005-50819719 (-)
CAST/EiJ	MGP_CASTEiJ_G0033825	protein coding gene	Chr9:53003381-53045242 (-)
CBA/J	MGP_CBAJ_G0034474	protein coding gene	Chr9:56423842-56471340 (-)
DBA/2J	MGP_DBA2J_G0034633	protein coding gene	Chr9:51259582-51300510 (-)
FVB/NJ	MGP_FVBNJ_G0034575	protein coding gene	Chr9:50448676-50490314 (-)
LP/J	MGP_LPJ_G0034715	protein coding gene	Chr9:53370682-53418677 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034618	protein coding gene	Chr9:58001974-58050641 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035334	protein coding gene	Chr9:52523229-52566446 (-)
PWK/PhJ	MGP_PWKPhJ_G0033529	protein coding gene	Chr9:51240337-51281196 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033364	protein coding gene	Chr9:52787696-52840033 (-)
WSB/EiJ	MGP_WSBEiJ_G0033937	protein coding gene	Chr9:52512072-52557472 (-)

Human Ortholog

TNFAIP8L3, TNF alpha induced protein 8 like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFAIP8L3, TNF alpha induced protein 8 like 3
Synonyms

TIPE3
Links

HGNC:20620

NCBI Gene ID: 388121

neXtProt AC: NX_Q5GJ75

UniProt: Q5GJ75
Chr Location

15q21.2; chr15:51056598-51105276 (-) GRCh38

MGI Vertebrate Homology

Tnfaip8l3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFAIP8L3
Gene Tree

Tnfaip8l3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

1
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Tnfaip8l3
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a null allele show delayed skin tumor onset and reduced tumor size after chemical induction with a carcinogen.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tnfaip8l3

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS40641.1

Ensembl

ENSMUSG00000074345 (Evidence)
NCBI Gene

244882

			Length	Strain/Species	Flank
genomic	244882	NCBI Gene Model \| MGI Sequence Detail	42806	C57BL/6J	± kb
transcript	NM_001033535	RefSeq \| MGI Sequence Detail	2225	C57BL/6
polypeptide	Q3TBL6	UniProt \| EBI \| MGI Sequence Detail	204	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016479 tumor necrosis factor alpha-induced protein 8-like protein 3

(term hierarchy)
InterPro Domains

IPR008477 Tumor necrosis factor alpha-induced protein 8-like

IPR038355 Tumor necrosis factor alpha-induced protein 8-like superfamily

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 29

Gene Ontology 7

Phenotypes 9
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:258238 Krey JF, et al., ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci. 2018 Jan 24;38(4):843-857

TSS for Tnfaip8l3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89624	Chr9:53975845-53975853 (-)	-154 bp
Tssr89623	Chr9:53975753-53975796 (-)	-80 bp
Tssr89622	Chr9:53975630-53975700 (-)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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