Bcl2l15 MGI Mouse Gene Detail - MGI:2685412

Symbol

Bcl2l15
Name

BCLl2-like 15
Synonyms

Bfk, LOC229672

Feature Type

protein coding gene
IDs

MGI:2685412
NCBI Gene: 229672
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr3:103739917-103761934 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.52 cM
Mapping Data

1 experiment

SNPs within 2kb

247 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685412	protein coding gene	Chr3:103738331-103761934 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027701	protein coding gene	Chr3:105122842-105148690 (+)
A/J	MGP_AJ_G0027661	protein coding gene	Chr3:101776759-101803855 (+)
AKR/J	MGP_AKRJ_G0027626	protein coding gene	Chr3:104259736-104283516 (+)
BALB/cJ	MGP_BALBcJ_G0027673	protein coding gene	Chr3:101546215-101569931 (+)
C3H/HeJ	MGP_C3HHeJ_G0027403	protein coding gene	Chr3:104629194-104652975 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028117	protein coding gene	Chr3:109015825-109041848 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025457	protein coding gene	Chr3:97904347-97925751 (+)
CAST/EiJ	MGP_CASTEiJ_G0026859	protein coding gene	Chr3:103745855-103768491 (+)
CBA/J	MGP_CBAJ_G0027378	protein coding gene	Chr3:112762052-112785914 (+)
DBA/2J	MGP_DBA2J_G0027520	protein coding gene	Chr3:101022359-101046919 (+)
FVB/NJ	MGP_FVBNJ_G0027488	protein coding gene	Chr3:98949622-98972205 (+)
LP/J	MGP_LPJ_G0027627	protein coding gene	Chr3:106467315-106491905 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027518	protein coding gene	Chr3:118870709-118895029 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028172	protein coding gene	Chr3:103815670-103839952 (+)
PWK/PhJ	MGP_PWKPhJ_G0026585	protein coding gene	Chr3:100794189-100817743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026406	protein coding gene	Chr3:101875930-101901923 (+)
WSB/EiJ	MGP_WSBEiJ_G0026939	protein coding gene	Chr3:104364763-104391199 (+)

Human Ortholog

BCL2L15, BCL2 like 15

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL2L15, BCL2 like 15
Synonyms

Bfk, C1orf178
Links

HGNC:33624

NCBI Gene ID: 440603

neXtProt AC: NX_Q5TBC7

UniProt: Q5TBC7
Chr Location

1p13.2; chr1:113876816-113887581 (-) GRCh38

MGI Vertebrate Homology

Bcl2l15 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BCL2L15
Gene Tree

Bcl2l15

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Bcl2l15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

24

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

8
UniProt

2
CCDS

CCDS51027.1, CCDS51028.1

Ensembl

ENSMUSG00000044165 (Evidence)
NCBI Gene

229672

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044165	Ensembl Gene Model \| MGI Sequence Detail	22018	C57BL/6J	± kb
transcript	ENSMUST00000062945	Ensembl \| MGI Sequence Detail	833	Not Applicable
polypeptide	ENSMUSP00000052210	Ensembl \| MGI Sequence Detail	167	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004697 Bcl-2-like protein 15

(term hierarchy)
InterPro Domains

IPR033543 Bcl-2-like protein 15

IPR036834 Bcl-2-like superfamily

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All nucleic 24

cDNA 24

Microarray probesets 4

Summaries

All 32

Diseases 1

Gene Ontology 3

Phenotypes 11
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bcl2l15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31001	Chr3:103739878-103739883 (+)	-36 bp
Tssr31002	Chr3:103740011-103740043 (+)	110 bp
Tssr31003	Chr3:103740057-103740156 (+)	190 bp
Tssr31004	Chr3:103740164-103740170 (+)	250 bp
Tssr31005	Chr3:103740182-103740193 (+)	271 bp
Tssr31006	Chr3:103743384-103743395 (+)	3,473 bp
Tssr31007	Chr3:103754123-103754134 (+)	14,212 bp
Tssr31008	Chr3:103754151-103754171 (+)	14,244 bp
Tssr31009	Chr3:103754173-103754181 (+)	14,260 bp
Tssr31010	Chr3:103754210-103754218 (+)	14,297 bp
Tssr31011	Chr3:103758558-103758565 (+)	18,645 bp
Tssr31012	Chr3:103758585-103758595 (+)	18,673 bp
Tssr31013	Chr3:103758605-103758620 (+)	18,696 bp
Tssr31014	Chr3:103758624-103758639 (+)	18,715 bp
Tssr31015	Chr3:103758649-103758660 (+)	18,738 bp
Tssr31016	Chr3:103760560-103760569 (+)	20,648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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