Ajap1 MGI Mouse Gene Detail - MGI:2685419 - adherens junction associated protein 1

Symbol

Ajap1
Name

adherens junction associated protein 1
Synonyms

LOC230959

Feature Type

protein coding gene
IDs

MGI:2685419
NCBI Gene: 230959
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr4:153457678-153567268 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 83.71 cM
Mapping Data

1 experiment

SNPs within 2kb

3367 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685419	protein coding gene	Chr4:153457678-153568313 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029184	protein coding gene	Chr4:157568737-157683103 (-)
A/J	MGP_AJ_G0029149	protein coding gene	Chr4:150960377-151077781 (-)
AKR/J	MGP_AKRJ_G0029097	protein coding gene	Chr4:155082326-155201015 (-)
BALB/cJ	MGP_BALBcJ_G0029165	protein coding gene	Chr4:151433880-151545902 (-)
C3H/HeJ	MGP_C3HHeJ_G0028886	protein coding gene	Chr4:155618177-155739233 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029614	protein coding gene	Chr4:163237893-163351641 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026860	protein coding gene	Chr4:143282539-143391598 (-)
CAST/EiJ	MGP_CASTEiJ_G0028299	protein coding gene	Chr4:152996196-153115252 (-)
CBA/J	MGP_CBAJ_G0028848	protein coding gene	Chr4:168129588-168265732 (-)
DBA/2J	MGP_DBA2J_G0028997	protein coding gene	Chr4:150989848-151103388 (-)
FVB/NJ	MGP_FVBNJ_G0028961	protein coding gene	Chr4:150177933-150290848 (-)
LP/J	MGP_LPJ_G0029087	protein coding gene	Chr4:157494726-157612643 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028988	protein coding gene	Chr4:171040569-171170457 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029646	protein coding gene	Chr4:155635530-155750866 (-)
PWK/PhJ	MGP_PWKPhJ_G0028019	protein coding gene	Chr4:146905840-147185310 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027853	protein coding gene	Chr4:149913244-150027048 (-)
WSB/EiJ	MGP_WSBEiJ_G0028379	protein coding gene	Chr4:155797320-155909229 (-)

Human Ortholog

AJAP1, adherens junctions associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AJAP1, adherens junctions associated protein 1
Synonyms

MOT8, SHREW-1, SHREW1
Links

HGNC:30801

NCBI Gene ID: 55966

neXtProt AC: NX_Q9UKB5

UniProt: Q9UKB5
Chr Location

1p36.32; chr1:4654609-4792534 (+) GRCh38

MGI Vertebrate Homology

Ajap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AJAP1
Gene Tree

Ajap1

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

3 involving Ajap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit normal response to baclofen-induced reduction of evoked EPSC amplitude.

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

33
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ajap1

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All Sequences

39
RefSeq

5
UniProt

2
CCDS

CCDS38987.1

Ensembl

ENSMUSG00000039546 (Evidence)
NCBI Gene

230959

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039546	Ensembl Gene Model \| MGI Sequence Detail	109591	C57BL/6J	± kb
transcript	ENSMUST00000105646	Ensembl \| MGI Sequence Detail	3048	Not Applicable
polypeptide	ENSMUSP00000101271	Ensembl \| MGI Sequence Detail	412	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003877 adherens junction-associated protein 1

(term hierarchy)
InterPro Domains

IPR039239 Adherens junction-associated protein 1

IPR029198 AJAP1/PANP, C-terminal

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All nucleic 9

cDNA 9

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 10
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ajap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44846	Chr4:153568428-153568432 (-)	-1,162 bp
Tssr44845	Chr4:153567396-153567429 (-)	-145 bp
Tssr44844	Chr4:153567225-153567244 (-)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24