Asap2 MGI Mouse Gene Detail - MGI:2685438 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Symbol

Asap2
Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms

6530401G17Rik, Ddef2, LOC385250

Feature Type

protein coding gene
IDs

MGI:2685438
NCBI Gene: 211914
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:21161369-21320172 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.29 cM
Mapping Data

1 experiment

SNPs within 2kb

4285 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685438	protein coding gene	Chr12:21040460-21320172 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019621	protein coding gene	Chr12:18718109-18820014 (+)
A/J	MGP_AJ_G0019588	protein coding gene	Chr12:18014374-18113655 (+)
AKR/J	MGP_AKRJ_G0019559	protein coding gene	Chr12:18840633-18947448 (+)
BALB/cJ	MGP_BALBcJ_G0019565	protein coding gene	Chr12:18391940-18488448 (+)
C3H/HeJ	MGP_C3HHeJ_G0019369	protein coding gene	Chr12:18733078-18838883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020013	protein coding gene	Chr12:19408583-19516323 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017638	protein coding gene	Chr12:17613815-17712723 (+)
CAST/EiJ	MGP_CASTEiJ_G0018924	protein coding gene	Chr12:15898488-16113423 (+)
CBA/J	MGP_CBAJ_G0019341	protein coding gene	Chr12:20140282-20252814 (+)
DBA/2J	MGP_DBA2J_G0019454	protein coding gene	Chr12:18046023-18146369 (+)
FVB/NJ	MGP_FVBNJ_G0019445	protein coding gene	Chr12:17947061-18047945 (+)
LP/J	MGP_LPJ_G0019524	protein coding gene	Chr12:18816841-18921254 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019480	protein coding gene	Chr12:19971283-20075712 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020052	protein coding gene	Chr12:18421793-18523319 (+)
PWK/PhJ	MGP_PWKPhJ_G0018690	protein coding gene	Chr12:15313546-15415831 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018479	protein coding gene	Chr12:15708743-15810406 (+)
WSB/EiJ	MGP_WSBEiJ_G0018975	protein coding gene	Chr12:18602208-18707635 (+)

Human Ortholog

ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms

AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
Links

HGNC:2721

NCBI Gene ID: 8853

neXtProt AC: NX_O43150

UniProt: O43150
Chr Location

2p25; chr2:9206765-9405683 (+) GRCh38

MGI Vertebrate Homology

Asap2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ASAP2
Gene Tree

Asap2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asap2

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All Sequences

69
RefSeq

21
UniProt

7
CCDS

CCDS49036.1, CCDS49037.1, CCDS56832.1

Ensembl

ENSMUSG00000052632 (Evidence)
NCBI Gene

211914

			Length	Strain/Species	Flank
genomic	211914	NCBI Gene Model \| MGI Sequence Detail	158804	C57BL/6J	± kb
transcript	NM_001135192	RefSeq \| MGI Sequence Detail	5686	C57BL/6
polypeptide	Q7SIG6	UniProt \| EBI \| MGI Sequence Detail	958	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004339 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

(term hierarchy)
PDB

1DCQ
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR043593 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein

IPR001164 Arf GTPase activating protein

IPR035677 ASAP2, SH3 domain

IPR037844 ASAP, PH domain

IPR004148 BAR domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q7SIG6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 2

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MGI:1923478, MGI:2686369

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Asap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112922	Chr12:21161721-21161777 (+)	380 bp
Tssr112923	Chr12:21161779-21161810 (+)	426 bp
Tssr112924	Chr12:21263041-21263061 (+)	101,682 bp
Tssr112925	Chr12:21264875-21264879 (+)	103,508 bp
Tssr112926	Chr12:21274287-21274324 (+)	112,937 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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