Jaml MGI Mouse Gene Detail - MGI:2685484 - junction adhesion molecule like

Symbol

Jaml
Name

junction adhesion molecule like
Synonyms

Amica1, LOC270152

Feature Type

protein coding gene
IDs

MGI:2685484
NCBI Gene: 270152
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:44990481-45019832 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

1 experiment

SNPs within 2kb

1016 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685484	protein coding gene	Chr9:44990451-45019832 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034729	protein coding gene	Chr9:43620749-43651315 (+)
A/J	MGP_AJ_G0034710	protein coding gene	Chr9:42404130-42434020 (+)
AKR/J	MGP_AKRJ_G0034637	protein coding gene	Chr9:43279261-43308333 (+)
BALB/cJ	MGP_BALBcJ_G0034701	protein coding gene	Chr9:42136004-42167545 (+)
C3H/HeJ	MGP_C3HHeJ_G0034412	protein coding gene	Chr9:43732337-43762634 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035222	protein coding gene	Chr9:44899387-44928393 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032137	protein coding gene	Chr9:41955551-41985542 (+)
CAST/EiJ	MGP_CASTEiJ_G0033734	protein coding gene	Chr9:43595913-43624756 (+)
CBA/J	MGP_CBAJ_G0034384	protein coding gene	Chr9:46547493-46581497 (+)
DBA/2J	MGP_DBA2J_G0034543	protein coding gene	Chr9:42293152-42322625 (+)
FVB/NJ	MGP_FVBNJ_G0034484	protein coding gene	Chr9:41550729-41580053 (+)
LP/J	MGP_LPJ_G0034624	protein coding gene	Chr9:43918410-43950363 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034528	protein coding gene	Chr9:48370919-48401223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035243	protein coding gene	Chr9:43197494-43228398 (+)
PWK/PhJ	MGP_PWKPhJ_G0033439	protein coding gene	Chr9:42179985-42209623 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033275	protein coding gene	Chr9:43486983-43517494 (+)
WSB/EiJ	MGP_WSBEiJ_G0033847	protein coding gene	Chr9:43224412-43254561 (+)

Human Ortholog

JAML, junction adhesion molecule like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JAML, junction adhesion molecule like
Synonyms

AMICA, AMICA1, CREA7-1, CREA7-4, Gm638
Links

HGNC:19084

NCBI Gene ID: 120425

neXtProt AC: NX_Q86YT9

UniProt: Q86YT9
Chr Location

11q23.3; chr11:118193725-118225092 (-) GRCh38

MGI Vertebrate Homology

Jaml stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: JAML
Gene Tree

Jaml

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in the kidney exhibit protection from induced kidney injury.

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All GO Annotations

23
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

17
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

56
RefSeq

14
UniProt

3
CCDS

CCDS23128.1

Ensembl

ENSMUSG00000048534 (Evidence)
NCBI Gene

270152

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048534	Ensembl Gene Model \| MGI Sequence Detail	29352	C57BL/6J	± kb
transcript	ENSMUST00000215880	Ensembl \| MGI Sequence Detail	1704	Not Applicable
polypeptide	ENSMUSP00000150697	Ensembl \| MGI Sequence Detail	379	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003990 junctional adhesion molecule-like

(term hierarchy)
PDB

3MJ6, 3MJ7, 3MJ9
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR000920 Myelin P0 protein-related
GlyGen

Q80UL9 3 sites

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All nucleic 18

cDNA 17

Other 1

Microarray probesets 1

Summaries

All 28

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 6
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:300243 Fu Y, et al., Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism. Cell Metab. 2020 Dec 1;32(6):1052-1062.e8

TSS for Jaml:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84722	Chr9:44990468-44990501 (+)	4 bp
Tssr84723	Chr9:44990502-44990534 (+)	37 bp
Tssr84724	Chr9:44997928-44997947 (+)	7,457 bp
Tssr84725	Chr9:45014172-45014182 (+)	23,696 bp
Tssr84726	Chr9:45015134-45015160 (+)	24,666 bp
Tssr84727	Chr9:45015164-45015191 (+)	24,697 bp
Tssr84728	Chr9:45015192-45015218 (+)	24,724 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24