Tmem132e MGI Mouse Gene Detail - MGI:2685490

Symbol

Tmem132e
Name

transmembrane protein 132E
Synonyms

LOC270893

Feature Type

protein coding gene
IDs

MGI:2685490
NCBI Gene: 270893
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:82279726-82337158 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.08 cM
Mapping Data

1 experiment

SNPs within 2kb

1624 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685490	protein coding gene	Chr11:82279281-82338447 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018827	protein coding gene	Chr11:83643454-83702260 (+)
A/J	MGP_AJ_G0018794	protein coding gene	Chr11:80428497-80487128 (+)
AKR/J	MGP_AKRJ_G0018764	protein coding gene	Chr11:82829250-82890442 (+)
BALB/cJ	MGP_BALBcJ_G0018767	protein coding gene	Chr11:80830995-80888371 (+)
C3H/HeJ	MGP_C3HHeJ_G0018581	protein coding gene	Chr11:82882233-82943680 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019219	protein coding gene	Chr11:86152695-86216253 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016853	protein coding gene	Chr11:77394825-77452245 (+)
CAST/EiJ	MGP_CASTEiJ_G0018136	protein coding gene	Chr11:83444956-83507668 (+)
CBA/J	MGP_CBAJ_G0018552	protein coding gene	Chr11:89923844-89987119 (+)
DBA/2J	MGP_DBA2J_G0018660	protein coding gene	Chr11:79990841-80048831 (+)
FVB/NJ	MGP_FVBNJ_G0018649	protein coding gene	Chr11:79531619-79593202 (+)
LP/J	MGP_LPJ_G0018730	protein coding gene	Chr11:84169918-84231328 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018676	protein coding gene	Chr11:90097435-90162457 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019259	protein coding gene	Chr11:83092160-83152333 (+)
PWK/PhJ	MGP_PWKPhJ_G0017906	protein coding gene	Chr11:80823117-80885193 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017697	protein coding gene	Chr11:82714147-82780006 (+)
WSB/EiJ	MGP_WSBEiJ_G0018188	protein coding gene	Chr11:82983405-83044622 (+)

Human Ortholog

TMEM132E, transmembrane protein 132E

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM132E, transmembrane protein 132E
Synonyms

DFNB99
Links

HGNC:26991

NCBI Gene ID: 124842

neXtProt AC: NX_Q6IEE7

UniProt: Q6IEE7
Chr Location

17q12; chr17:34579487-34639318 (+) GRCh38

MGI Vertebrate Homology

Tmem132e stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM132E
Gene Tree

Tmem132e

Diseases

1 with human TMEM132E associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 99 IDs autosomal recessive nonsyndromic deafness 99 DOID:0111634 OMIM:618481

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

2 involving Tmem132e
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available

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All GO Annotations

3
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

19
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

9
UniProt

2
CCDS

CCDS25144.2

Ensembl

ENSMUSG00000020701 (Evidence)
NCBI Gene

270893

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020701	Ensembl Gene Model \| MGI Sequence Detail	57433	C57BL/6J	± kb
transcript	ENSMUST00000054245	Ensembl \| MGI Sequence Detail	4386	Not Applicable
polypeptide	ENSMUSP00000052484	Ensembl \| MGI Sequence Detail	1074	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030801 transmembrane protein 132E

(term hierarchy)
InterPro Domains

IPR026307 Transmembrane protein 132

IPR031437 Transmembrane protein family 132, middle domain

IPR031436 Transmembrane protein TMEM132, C-terminal

IPR031435 Transmembrane protein TMEM132, N-terminal
GlyGen

Q6IEE6 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 17

cDNA 15

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem132e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103574	Chr11:82278267-82278328 (+)	-1,428 bp
Tssr103575	Chr11:82278383-82278394 (+)	-1,337 bp
Tssr103576	Chr11:82279720-82279775 (+)	22 bp
Tssr103577	Chr11:82325657-82325659 (+)	45,932 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24