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Arhgef40 Gene Detail
Summary
  • Symbol
    Arhgef40
  • Name
    Rho guanine nucleotide exchange factor 40
  • Synonyms
    E130112L23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685515
    NCBI Gene: 268739
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:52222176-52243708 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    489 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685515
 protein coding gene Chr14:52222158-52243708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021286
 protein coding gene Chr14:45995358-46016540 (+)
A/J MGP_AJ_G0021243
 protein coding gene Chr14:44802889-44827349 (+)
AKR/J MGP_AKRJ_G0021219
 protein coding gene Chr14:46419000-46440235 (+)
BALB/cJ MGP_BALBcJ_G0021247
 protein coding gene Chr14:44911204-44932428 (+)
C3H/HeJ MGP_C3HHeJ_G0021027
 protein coding gene Chr14:46231232-46252412 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021686
 protein coding gene Chr14:48028574-48053338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019231
 protein coding gene Chr14:43998832-44020421 (+)
CAST/EiJ MGP_CASTEiJ_G0020546
 protein coding gene Chr14:43203522-43225709 (+)
CBA/J MGP_CBAJ_G0020994
 protein coding gene Chr14:49495793-49518754 (+)
DBA/2J MGP_DBA2J_G0021115
 protein coding gene Chr14:44568918-44590067 (+)
FVB/NJ MGP_FVBNJ_G0021098
 protein coding gene Chr14:44158960-44180098 (+)
LP/J MGP_LPJ_G0021190
 protein coding gene Chr14:46598848-46620039 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021121
 protein coding gene Chr14:48948620-48969877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021713
 protein coding gene Chr14:45804938-45826163 (+)
PWK/PhJ MGP_PWKPhJ_G0020295
 protein coding gene Chr14:41322696-41344300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020122
 protein coding gene Chr14:41830174-41862639 (+)
WSB/EiJ MGP_WSBEiJ_G0020599
 protein coding gene Chr14:46125522-46147695 (+)



Homology
more
  • Human Ortholog
    ARHGEF40, Rho guanine nucleotide exchange factor 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF40, Rho guanine nucleotide exchange factor 40
  • Synonyms
    SOLO
  • Links
    NCBI Gene ID: 55701
    neXtProt AC: NX_Q8TER5
    UniProt: Q8TER5

  • Chr Location
    14q11.2; chr14:21061264-21090248 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004562 Ensembl Gene Model | MGI Sequence Detail 21533 C57BL/6J ±  kb
transcript ENSMUST00000182760 Ensembl | MGI Sequence Detail 5130 Not Applicable  
polypeptide ENSMUSP00000138125 Ensembl | MGI Sequence Detail 1526 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory