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Ctif Gene Detail
Summary
  • Symbol
    Ctif
  • Name
    CBP80/20-dependent translation initiation factor
  • Synonyms
    Gm672, LOC269037
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685518
    NCBI Gene: 269037
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:75564295-75830625 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 51.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685518
 protein coding gene Chr18:75564279-75830762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024565
 protein coding gene Chr18:76137739-76410064 (-)
A/J MGP_AJ_G0024532
 protein coding gene Chr18:72811365-73044032 (-)
AKR/J MGP_AKRJ_G0024503
 protein coding gene Chr18:74986709-75249700 (-)
BALB/cJ MGP_BALBcJ_G0024532
 protein coding gene Chr18:73005398-73274432 (-)
C3H/HeJ MGP_C3HHeJ_G0024300
 protein coding gene Chr18:75074614-75360604 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024978
 protein coding gene Chr18:78124249-78414185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022408
 protein coding gene Chr18:71861671-72133279 (-)
CAST/EiJ MGP_CASTEiJ_G0023773
 protein coding gene Chr18:75283161-75573994 (-)
CBA/J MGP_CBAJ_G0024269
 protein coding gene Chr18:80827514-81114382 (-)
DBA/2J MGP_DBA2J_G0024399
 protein coding gene Chr18:72388982-72660120 (-)
FVB/NJ MGP_FVBNJ_G0024365
 protein coding gene Chr18:71740264-72011161 (-)
LP/J MGP_LPJ_G0024483
 protein coding gene Chr18:76004787-76280058 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024395
 protein coding gene Chr18:82229221-82510398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025026
 protein coding gene Chr18:75101978-75384471 (-)
PWK/PhJ MGP_PWKPhJ_G0023517
 protein coding gene Chr18:72787246-73063468 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023321
 protein coding gene Chr18:75255557-75534582 (-)
WSB/EiJ MGP_WSBEiJ_G0023836
 protein coding gene Chr18:75053225-75328106 (-)



Homology
more
  • Human Ortholog
    CTIF, cap binding complex dependent translation initiation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTIF, cap binding complex dependent translation initiation factor
  • Synonyms
    Gm672, KIAA0427
  • Links
    NCBI Gene ID: 9811
    neXtProt AC: NX_O43310
    UniProt: O43310

  • Chr Location
    18q21.1; chr18:48539031-48863217 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    13
  • cDNA Data
    61
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052928 Ensembl Gene Model | MGI Sequence Detail 266331 C57BL/6J ±  kb
    transcript ENSMUST00000165559 Ensembl | MGI Sequence Detail 6031 Not Applicable  
    polypeptide ENSMUSP00000129974 Ensembl | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030883 CBP80/20-dependent translation initiation factor
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR003890 MIF4G-like, type 3
      IPR051367 mRNA Translation Regulation/Replication-dependent Histone mRNA Translation
    • GlyGen
      Q6PEE2 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory