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Shroom4 Gene Detail
Summary
  • Symbol
    Shroom4
  • Name
    shroom family member 4
  • Synonyms
    D430043L16Rik, Shrm4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685570
    NCBI Gene: 208431
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:6312012-6549508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 2.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685570
 protein coding gene ChrX:6311908-6549508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035505
 protein coding gene ChrX:1026244-1269161 (+)
A/J MGP_AJ_G0035483
 protein coding gene ChrX:1013130-1241792 (+)
AKR/J MGP_AKRJ_G0035416
 protein coding gene ChrX:1047199-1299623 (+)
BALB/cJ MGP_BALBcJ_G0035479
 protein coding gene ChrX:1037784-1267487 (+)
C3H/HeJ MGP_C3HHeJ_G0035187
 protein coding gene ChrX:1046939-1280072 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036003
 protein coding gene ChrX:1081613-1329194 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032878
 protein coding gene ChrX:580386-803844 (+)
CAST/EiJ MGP_CASTEiJ_G0034487
 protein coding gene ChrX:953693-1200933 (+)
CBA/J MGP_CBAJ_G0035157
 protein coding gene ChrX:1148123-1404498 (+)
DBA/2J MGP_DBA2J_G0035314
 protein coding gene ChrX:1042921-1282003 (+)
FVB/NJ MGP_FVBNJ_G0035261
 protein coding gene ChrX:1001370-1240324 (+)
LP/J MGP_LPJ_G0035391
 protein coding gene ChrX:1030606-1274253 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035300
 protein coding gene ChrX:1089501-1356776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036021
 protein coding gene ChrX:1016451-1263162 (+)
PWK/PhJ MGP_PWKPhJ_G0034189
 protein coding gene ChrX:971569-1193293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034026
 protein coding gene ChrX:947439-1196367 (+)
WSB/EiJ MGP_WSBEiJ_G0034610
 protein coding gene ChrX:1024763-1262740 (+)



Homology
more
  • Human Ortholog
    SHROOM4, shroom family member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHROOM4, shroom family member 4
  • Synonyms
    MRXSSDS, SHAP, shrm4
  • Links
    NCBI Gene ID: 57477
    neXtProt AC: NX_Q9ULL8
    UniProt: Q9ULL8

  • Chr Location
    Xp11.22; chrX:50575534-50814302 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    23
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208431 NCBI Gene Model | MGI Sequence Detail 237497 C57BL/6J ±  kb
    transcript NM_001040459 RefSeq | MGI Sequence Detail 8278 Not Specified  
    polypeptide Q1W617 UniProt | EBI | MGI Sequence Detail 1475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:114885 Dietz ML, et al., Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. J Biol Chem. 2006 Jul 21;281(29):20542-54
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory