Rasl10b MGI Mouse Gene Detail - MGI:2685575 - RAS-like, family 10, member B

Symbol

Rasl10b
Name

RAS-like, family 10, member B
Synonyms

B230331P10Rik, VTS58635

Feature Type

protein coding gene
IDs

MGI:2685575
NCBI Gene: 276952
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:83299963-83311865 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM
Mapping Data

1 experiment

SNPs within 2kb

307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685575	protein coding gene	Chr11:83299963-83311865 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018846	protein coding gene	Chr11:84730450-84742323 (+)
A/J	MGP_AJ_G0018813	protein coding gene	Chr11:81519269-81531142 (+)
AKR/J	MGP_AKRJ_G0018783	protein coding gene	Chr11:83944660-83956533 (+)
BALB/cJ	MGP_BALBcJ_G0018786	protein coding gene	Chr11:81930589-81942491 (+)
C3H/HeJ	MGP_C3HHeJ_G0018600	protein coding gene	Chr11:84004497-84016370 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019238	protein coding gene	Chr11:87329660-87341562 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016872	protein coding gene	Chr11:78645700-78657421 (+)
CAST/EiJ	MGP_CASTEiJ_G0018155	protein coding gene	Chr11:84581296-84592585 (+)
CBA/J	MGP_CBAJ_G0018571	protein coding gene	Chr11:91103508-91115381 (+)
DBA/2J	MGP_DBA2J_G0018679	protein coding gene	Chr11:81115573-81127666 (+)
FVB/NJ	MGP_FVBNJ_G0018668	protein coding gene	Chr11:80598296-80610198 (+)
LP/J	MGP_LPJ_G0018749	protein coding gene	Chr11:85296457-85308330 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018695	protein coding gene	Chr11:91271878-91283780 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019278	protein coding gene	Chr11:84213231-84225108 (+)
PWK/PhJ	MGP_PWKPhJ_G0017924	protein coding gene	Chr11:81875172-81887155 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017716	protein coding gene	Chr11:83752331-83764217 (+)
WSB/EiJ	MGP_WSBEiJ_G0018206	protein coding gene	Chr11:84078127-84090011 (+)

Human Ortholog

RASL10B, RAS like family 10 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASL10B, RAS like family 10 member B
Synonyms

RRP17, VTS58635
Links

HGNC:30295

NCBI Gene ID: 91608

neXtProt AC: NX_Q96S79

UniProt: Q96S79
Chr Location

17q12; chr17:35731639-35743521 (+) GRCh38

MGI Vertebrate Homology

Rasl10b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASL10B
Gene Tree

Rasl10b

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

2 involving Rasl10b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele have smaller than normal large dense-core vesicles in atrial myocytes and exhibit impaired atrial natriuretic peptide secretion.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

31
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rasl10b

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All Sequences

51
RefSeq

10
UniProt

2
CCDS

CCDS25163.1, CCDS88208.1

Ensembl

ENSMUSG00000020684 (Evidence)
NCBI Gene

276952

			Length	Strain/Species	Flank
genomic	276952	NCBI Gene Model \| MGI Sequence Detail	11903	C57BL/6J	± kb
transcript	NM_001013386	RefSeq \| MGI Sequence Detail	3482	C57BL/6
polypeptide	Q5SSG5	UniProt \| EBI \| MGI Sequence Detail	203	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031853 Ras-like protein family member 10B

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR052661 Ras-like GTPase Regulators

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Rasl10b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103692	Chr11:83300042-83300115 (+)	116 bp
Tssr103693	Chr11:83300481-83300544 (+)	550 bp
Tssr103694	Chr11:83300546-83300553 (+)	587 bp
Tssr103695	Chr11:83300562-83300575 (+)	606 bp
Tssr103696	Chr11:83309787-83309803 (+)	9,832 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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