Rubcnl MGI Mouse Gene Detail - MGI:2685590 - RUN and cysteine rich domain containing beclin 1 interacting protein like

Symbol

Rubcnl
Name

RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms

5031414D18Rik, LOC380917

Feature Type

protein coding gene
IDs

MGI:2685590
NCBI Gene: 271221
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:75253467-75289972 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 39.53 cM
Mapping Data

1 experiment

SNPs within 2kb

1343 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685590	protein coding gene	Chr14:75253467-75289977 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021565	protein coding gene	Chr14:69814761-69853172 (+)
A/J	MGP_AJ_G0021523	protein coding gene	Chr14:68263700-68301639 (+)
AKR/J	MGP_AKRJ_G0021500	protein coding gene	Chr14:70285022-70321529 (+)
BALB/cJ	MGP_BALBcJ_G0021530	protein coding gene	Chr14:68062902-68099483 (+)
C3H/HeJ	MGP_C3HHeJ_G0021307	protein coding gene	Chr14:70021298-70059394 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021970	protein coding gene	Chr14:72879544-72918557 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019508	protein coding gene	Chr14:65908252-65944984 (+)
CAST/EiJ	MGP_CASTEiJ_G0020824	protein coding gene	Chr14:66680485-66721738 (+)
CBA/J	MGP_CBAJ_G0021275	protein coding gene	Chr14:75208224-75250269 (+)
DBA/2J	MGP_DBA2J_G0021398	protein coding gene	Chr14:67673942-67710868 (+)
FVB/NJ	MGP_FVBNJ_G0021376	protein coding gene	Chr14:67004352-67040720 (+)
LP/J	MGP_LPJ_G0021468	protein coding gene	Chr14:70975861-71015523 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021403	protein coding gene	Chr14:73997294-74033951 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021993	protein coding gene	Chr14:69579627-69616871 (+)
PWK/PhJ	MGP_PWKPhJ_G0020567	protein coding gene	Chr14:64411093-64445658 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020403	protein coding gene	Chr14:65522189-65564535 (+)
WSB/EiJ	MGP_WSBEiJ_G0020877	protein coding gene	Chr14:69912773-69950712 (+)

Human Ortholog

RUBCNL, rubicon like autophagy enhancer

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RUBCNL, rubicon like autophagy enhancer
Synonyms

C13orf18, KIAA0226L, PACER
Links

HGNC:20420

NCBI Gene ID: 80183

neXtProt AC: NX_Q9H714

UniProt: Q9H714
Chr Location

13q14.13; chr13:46334681-46438190 (-) GRCh38

MGI Vertebrate Homology

Rubcnl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RUBCNL
Gene Tree

Rubcnl

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Rubcnl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rubcnl

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All Sequences

45
RefSeq

14
UniProt

4
CCDS

CCDS36977.1

Ensembl

ENSMUSG00000034959 (Evidence)
NCBI Gene

271221

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034959	Ensembl Gene Model \| MGI Sequence Detail	36506	C57BL/6J	± kb
transcript	ENSMUST00000036072	Ensembl \| MGI Sequence Detail	2651	Not Applicable
polypeptide	ENSMUSP00000045566	Ensembl \| MGI Sequence Detail	675	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000060085 protein associated with UVRAG as autophagy enhancer

(term hierarchy)
InterPro Domains

IPR052428 Autophagy and Host Defense Regulator

IPR025258 Rubicon Homology Domain

IPR048569 Rubicon, PI3K-binding domain

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All nucleic 12

cDNA 12

Microarray probesets 1

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MGI:2685757

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:272052 Cheng X, et al., Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell. 2019 Feb 21;73(4):788-802.e7

TSS for Rubcnl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126602	Chr14:75253454-75253463 (+)	-8 bp
Tssr126603	Chr14:75253468-75253485 (+)	10 bp
Tssr126604	Chr14:75253488-75253514 (+)	34 bp
Tssr126605	Chr14:75289819-75289823 (+)	36,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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