Card9 MGI Mouse Gene Detail - MGI:2685628 - caspase recruitment domain family, member 9

Symbol

Card9
Name

caspase recruitment domain family, member 9
Synonyms

LOC332579

Feature Type

protein coding gene
IDs

MGI:2685628
NCBI Gene: 332579
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:26242188-26250930 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 18.87 cM
Mapping Data

1 experiment

SNPs within 2kb

254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685628	protein coding gene	Chr2:26242188-26250957 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025484	protein coding gene	Chr2:24300431-24309254 (-)
A/J	MGP_AJ_G0025461	protein coding gene	Chr2:23369411-23378139 (-)
AKR/J	MGP_AKRJ_G0025431	protein coding gene	Chr2:24131544-24140278 (-)
BALB/cJ	MGP_BALBcJ_G0025457	protein coding gene	Chr2:23478059-23486852 (-)
C3H/HeJ	MGP_C3HHeJ_G0025218	protein coding gene	Chr2:24089118-24097857 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025901	protein coding gene	Chr2:25084186-25092924 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023312	protein coding gene	Chr2:22248182-22257145 (-)
CAST/EiJ	MGP_CASTEiJ_G0024681	protein coding gene	Chr2:23963121-23971940 (-)
CBA/J	MGP_CBAJ_G0025196	protein coding gene	Chr2:25930174-25942312 (-)
DBA/2J	MGP_DBA2J_G0025329	protein coding gene	Chr2:23191031-23199768 (-)
FVB/NJ	MGP_FVBNJ_G0025291	protein coding gene	Chr2:22942695-22951437 (-)
LP/J	MGP_LPJ_G0025415	protein coding gene	Chr2:24246905-24255728 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025322	protein coding gene	Chr2:26083307-26092043 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025960	protein coding gene	Chr2:24087810-24096630 (-)
PWK/PhJ	MGP_PWKPhJ_G0024429	protein coding gene	Chr2:22993919-23002682 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024229	protein coding gene	Chr2:24217913-24226563 (-)
WSB/EiJ	MGP_WSBEiJ_G0024750	protein coding gene	Chr2:24195981-24204712 (-)

Human Ortholog

CARD9, caspase recruitment domain family member 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARD9, caspase recruitment domain family member 9
Synonyms

CANDF2, hCARD9, IMD103
Links

HGNC:16391

NCBI Gene ID: 64170

neXtProt AC: NX_Q9H257

UniProt: Q9H257
Chr Location

9q34.3; chr9:136363956-136373681 (-) GRCh38

MGI Vertebrate Homology

Card9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARD9
Gene Tree

Card9

Diseases

1 with human CARD9 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
103 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

3
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for one allele of this gene display impaired immune responses to fungal infection but normal rates of bacterial clearance. However, homozygotes for a second allele display impaired bacterial clearance and impaired early innate immune responses.

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All GO Annotations

74
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase card9

ZFIN card9

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All Sequences

33
RefSeq

4
UniProt

2
CCDS

CCDS38084.1

Ensembl

ENSMUSG00000026928 (Evidence)
NCBI Gene

332579

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026928	Ensembl Gene Model \| MGI Sequence Detail	8743	C57BL/6J	± kb
transcript	ENSMUST00000028294	Ensembl \| MGI Sequence Detail	1880	Not Applicable
polypeptide	ENSMUSP00000028294	Ensembl \| MGI Sequence Detail	536	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005041 caspase recruitment domain-containing protein 9

(term hierarchy)
InterPro Domains

IPR042142 CARD9, CARD domain

IPR001315 CARD domain

IPR011029 Death-like domain superfamily

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 133

Gene Ontology 18

Phenotypes 103
Earliest

J:111706 Gross O, et al., Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006 Aug 10;442(7103):651-6
Latest

J:346465 Brandt M, et al., Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses. Cell Rep. 2024 Mar 13;43(3):113944

TSS for Card9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23102	Chr2:26250885-26250926 (-)	24 bp
Tssr23101	Chr2:26250855-26250884 (-)	60 bp
Tssr23100	Chr2:26246850-26246917 (-)	4,046 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24