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Grxcr2 Gene Detail
Summary
  • Symbol
    Grxcr2
  • Name
    glutaredoxin, cysteine rich 2
  • Synonyms
    LOC332309
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685697
    NCBI Gene: 332309
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:42118388-42132114 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 22.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    473 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685697
 protein coding gene Chr18:42118388-42132114 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024374
 protein coding gene Chr18:40582688-40597077 (-)
A/J MGP_AJ_G0024341
 protein coding gene Chr18:39196629-39209498 (-)
AKR/J MGP_AKRJ_G0024310
 protein coding gene Chr18:40259387-40272226 (-)
BALB/cJ MGP_BALBcJ_G0024341
 protein coding gene Chr18:39259918-39276574 (-)
C3H/HeJ MGP_C3HHeJ_G0024107
 protein coding gene Chr18:40315237-40328128 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024783
 protein coding gene Chr18:42030943-42043657 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022222
 protein coding gene Chr18:39023173-39035653 (-)
CAST/EiJ MGP_CASTEiJ_G0023582
 protein coding gene Chr18:40267056-40281098 (-)
CBA/J MGP_CBAJ_G0024077
 protein coding gene Chr18:43301476-43314263 (-)
DBA/2J MGP_DBA2J_G0024207
 protein coding gene Chr18:38773770-38786705 (-)
FVB/NJ MGP_FVBNJ_G0024173
 protein coding gene Chr18:38416383-38431864 (-)
LP/J MGP_LPJ_G0024291
 protein coding gene Chr18:40652322-40666130 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024204
 protein coding gene Chr18:44540465-44553355 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024832
 protein coding gene Chr18:40146497-40159443 (-)
PWK/PhJ MGP_PWKPhJ_G0023326
 protein coding gene Chr18:38989932-39002987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023131
 protein coding gene Chr18:40381776-40400530 (-)
WSB/EiJ MGP_WSBEiJ_G0023645
 protein coding gene Chr18:40061597-40074468 (-)



Homology
more
  • Human Ortholog
    GRXCR2, glutaredoxin and cysteine rich domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRXCR2, glutaredoxin and cysteine rich domain containing 2
  • Synonyms
    DFNB101
  • Links
    NCBI Gene ID: 643226
    neXtProt AC: NX_A6NFK2
    UniProt: A6NFK2

  • Chr Location
    5q32; chr5:145857670-145937126 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRXCR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 332309 NCBI Gene Model | MGI Sequence Detail 13727 C57BL/6J ±  kb
    transcript NM_001033426 RefSeq | MGI Sequence Detail 1998 C57BL/6  
    polypeptide Q3TYR5 UniProt | EBI | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031772 glutaredoxin domain-containing cysteine-rich protein 2
      (term hierarchy)
    • InterPro Domains
      IPR033023 Glutaredoxin domain-containing cysteine-rich protein 2
      IPR036410 Heat shock protein DnaJ, cysteine-rich domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:329331 Li J, et al., RIPOR2-mediated autophagy dysfunction is critical for aminoglycoside-induced hearing loss. Dev Cell. 2022 Sep 26;57(18):2204-2220.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory