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Ldc1 Gene Detail
Summary
  • Symbol
    Ldc1
  • Name
    leucine decarboxylase 1
  • Synonyms
    Gm853, LOC332942
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685699
    NCBI Gene: 332942
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130102902-130116194 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685699
 protein coding gene Chr4:130102816-130116221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028846
 protein coding gene Chr4:132202210-132215469 (-)
A/J MGP_AJ_G0028805
 protein coding gene Chr4:126901294-126914726 (-)
AKR/J MGP_AKRJ_G0028758
 protein coding gene Chr4:130457550-130470595 (-)
BALB/cJ MGP_BALBcJ_G0028828
 protein coding gene Chr4:127513132-127526492 (-)
C3H/HeJ MGP_C3HHeJ_G0028542
 protein coding gene Chr4:130514072-130527371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029270
 protein coding gene Chr4:137155406-137168690 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026542
 protein coding gene Chr4:120017525-120030877 (-)
CAST/EiJ MGP_CASTEiJ_G0027974
 protein coding gene Chr4:128724292-128738425 (-)
CBA/J MGP_CBAJ_G0028508
 protein coding gene Chr4:140636731-140650014 (-)
DBA/2J MGP_DBA2J_G0028657
 protein coding gene Chr4:127335466-127348761 (-)
FVB/NJ MGP_FVBNJ_G0028624
 protein coding gene Chr4:126121953-126135073 (-)
LP/J MGP_LPJ_G0028758
 protein coding gene Chr4:132528811-132542134 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028650
 protein coding gene Chr4:145346304-145359908 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029308
 protein coding gene Chr4:130823259-130836553 (-)
PWK/PhJ MGP_PWKPhJ_G0027696
 protein coding gene Chr4:123960433-123972567 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027522
 protein coding gene Chr4:126694925-126707752 (-)
WSB/EiJ MGP_WSBEiJ_G0028055
 protein coding gene Chr4:130976159-130990204 (-)



Homology
more
  • Human Ortholog
    LDC1P, leucine decarboxylase 1, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDC1P, leucine decarboxylase 1, pseudogene
  • Synonyms
    LINC01225
  • Links
    NCBI Gene ID: 149086

  • Chr Location
    1p35.2; chr1:31500085-31509648 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023120 Ensembl Gene Model | MGI Sequence Detail 13293 C57BL/6J ±  kb
transcript ENSMUST00000023884 Ensembl | MGI Sequence Detail 2314 Not Applicable  
polypeptide ENSMUSP00000023884 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
    IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site
    IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
    IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
    IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site
    IPR000183 Ornithine/DAP/Arg decarboxylase
    IPR002433 Ornithine decarboxylase
    IPR029066 PLP-binding barrel
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
Other
Accession IDs
less
MGI:3841243, MGI:6304470
References
more
  • Summaries
    All 19
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:255630 Lambertos A, et al., The mouse Gm853 gene encodes a novel enzyme: Leucine decarboxylase. Biochim Biophys Acta. 2017 Nov 4;1862(3):365-376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory