Milr1 MGI Mouse Gene Detail - MGI:2685731 - mast cell immunoglobulin like receptor 1

Symbol

Milr1
Name

mast cell immunoglobulin like receptor 1
Synonyms

Allergin-1, Gm885, LOC380732

Feature Type

protein coding gene
IDs

MGI:2685731
NCBI Gene: 380732
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:106642052-106659620 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.00 cM
Mapping Data

1 experiment

SNPs within 2kb

533 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685731	protein coding gene	Chr11:106641472-106659620 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019311	protein coding gene	Chr11:110084551-110102978 (+)
A/J	MGP_AJ_G0019279	protein coding gene	Chr11:105383240-105400840 (+)
AKR/J	MGP_AKRJ_G0019248	protein coding gene	Chr11:108521883-108541173 (+)
BALB/cJ	MGP_BALBcJ_G0019253	protein coding gene	Chr11:105798180-105815916 (+)
C3H/HeJ	MGP_C3HHeJ_G0019062	protein coding gene	Chr11:108819520-108838090 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019703	protein coding gene	Chr11:113483225-113502772 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017327	protein coding gene	Chr11:102651298-102669520 (+)
CAST/EiJ	MGP_CASTEiJ_G0018615	protein coding gene	Chr11:109904582-109923385 (+)
CBA/J	MGP_CBAJ_G0019031	protein coding gene	Chr11:118186698-118207627 (+)
DBA/2J	MGP_DBA2J_G0019143	protein coding gene	Chr11:104852769-104870240 (+)
FVB/NJ	MGP_FVBNJ_G0019134	protein coding gene	Chr11:104366510-104383906 (+)
LP/J	MGP_LPJ_G0019213	protein coding gene	Chr11:110532964-110552194 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019164	protein coding gene	Chr11:117422060-117443458 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019740	protein coding gene	Chr11:109041983-109061390 (+)
PWK/PhJ	MGP_PWKPhJ_G0018380	protein coding gene	Chr11:105967080-105985551 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018171	protein coding gene	Chr11:108818647-108834829 (+)
WSB/EiJ	MGP_WSBEiJ_G0018666	protein coding gene	Chr11:109014346-109035353 (+)

Human Ortholog

MILR1, mast cell immunoglobulin like receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MILR1, mast cell immunoglobulin like receptor 1
Synonyms

Allergin-1, C17orf60, MCA-32, MCA32
Links

HGNC:27570

NCBI Gene ID: 284021

neXtProt AC: NX_Q7Z6M3

UniProt: Q7Z6M3
Chr Location

17q23.3; chr17:64449037-64497356 (+) GRCh38

MGI Vertebrate Homology

Milr1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MILR1
Gene Tree

Milr1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

12
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have decreased mast cell degranulation and an increased susceptibility to type I hypersensitivity reaction.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

77
RefSeq

22
UniProt

5
CCDS

CCDS25560.1, CCDS70333.1, CCDS70334.1, CCDS70335.1

Ensembl

ENSMUSG00000040528 (Evidence)
NCBI Gene

380732

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040528	Ensembl Gene Model \| MGI Sequence Detail	17569	C57BL/6J	± kb
transcript	ENSMUST00000147326	Ensembl \| MGI Sequence Detail	1234	Not Applicable
polypeptide	ENSMUSP00000138742	Ensembl \| MGI Sequence Detail	246	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031783 allergin-1

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype
GlyGen

Q3TB92 1 site

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All nucleic 16

cDNA 16

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 15
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Milr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105548	Chr11:106641501-106641516 (+)	-543 bp
Tssr105549	Chr11:106642068-106642077 (+)	21 bp
Tssr105550	Chr11:106642081-106642106 (+)	42 bp
Tssr105551	Chr11:106642435-106642473 (+)	402 bp
Tssr105552	Chr11:106643287-106643298 (+)	1,241 bp
Tssr105553	Chr11:106645941-106645961 (+)	3,899 bp
Tssr105554	Chr11:106645974-106646010 (+)	3,940 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24