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Siah3 Gene Detail
Summary
  • Symbol
    Siah3
  • Name
    siah E3 ubiquitin protein ligase family member 3
  • Synonyms
    LOC380918
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685758
    NCBI Gene: 380918
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75693422-75767148 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 40.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685758
 protein coding gene Chr14:75693372-75767148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021570
 protein coding gene Chr14:70284316-70367263 (+)
A/J MGP_AJ_G0021528
 protein coding gene Chr14:68711330-68781968 (+)
AKR/J MGP_AKRJ_G0021505
 protein coding gene Chr14:70754891-70827204 (+)
BALB/cJ MGP_BALBcJ_G0021535
 protein coding gene Chr14:68506363-68576308 (+)
C3H/HeJ MGP_C3HHeJ_G0021312
 protein coding gene Chr14:70487767-70560996 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021975
 protein coding gene Chr14:73374214-73448458 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019513
 protein coding gene Chr14:66339545-66408490 (+)
CAST/EiJ MGP_CASTEiJ_G0020829
 protein coding gene Chr14:67142110-67219691 (+)
CBA/J MGP_CBAJ_G0021280
 protein coding gene Chr14:75718441-75801151 (+)
DBA/2J MGP_DBA2J_G0021403
 protein coding gene Chr14:68115579-68186421 (+)
FVB/NJ MGP_FVBNJ_G0021381
 protein coding gene Chr14:67455557-67528184 (+)
LP/J MGP_LPJ_G0021473
 protein coding gene Chr14:71455821-71530770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021408
 protein coding gene Chr14:74471874-74550750 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021998
 protein coding gene Chr14:70032280-70104658 (+)
PWK/PhJ MGP_PWKPhJ_G0020572
 protein coding gene Chr14:64848735-64921424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020409
 protein coding gene Chr14:65991159-66065923 (+)
WSB/EiJ MGP_WSBEiJ_G0020882
 protein coding gene Chr14:70370432-70446526 (+)



Homology
more
  • Human Ortholog
    SIAH3, siah E3 ubiquitin protein ligase family member 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIAH3, siah E3 ubiquitin protein ligase family member 3
  • Links
    NCBI Gene ID: 283514
    neXtProt AC: NX_Q8IW03
    UniProt: Q8IW03

  • Chr Location
    13q14.13; chr13:45777242-45851753 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091722 Ensembl Gene Model | MGI Sequence Detail 73727 C57BL/6J ±  kb
transcript ENSMUST00000164848 Ensembl | MGI Sequence Detail 4472 Not Applicable  
polypeptide ENSMUSP00000130827 Ensembl | MGI Sequence Detail 268 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory