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Npw Gene Detail
Summary
  • Symbol
    Npw
  • Name
    neuropeptide W
  • Synonyms
    LOC381073
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685781
    NCBI Gene: 381073
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24876304-24877431 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685781
 protein coding gene Chr17:24876303-24877526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023311
 protein coding gene Chr17:23656342-23657478 (-)
A/J MGP_AJ_G0023271
 protein coding gene Chr17:23016416-23017552 (-)
AKR/J MGP_AKRJ_G0023238
 protein coding gene Chr17:23096721-23097857 (-)
BALB/cJ MGP_BALBcJ_G0023276
 protein coding gene Chr17:23201808-23202944 (-)
C3H/HeJ MGP_C3HHeJ_G0023036
 protein coding gene Chr17:23456655-23457791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023720
 protein coding gene Chr17:24707686-24708813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021195
 protein coding gene Chr17:20490286-20491408 (-)
CAST/EiJ MGP_CASTEiJ_G0022538
 protein coding gene Chr17:23308583-23309721 (-)
CBA/J MGP_CBAJ_G0023012
 protein coding gene Chr17:25549828-25550964 (-)
DBA/2J MGP_DBA2J_G0023141
 protein coding gene Chr17:22605123-22606259 (-)
FVB/NJ MGP_FVBNJ_G0023111
 protein coding gene Chr17:22328950-22330088 (-)
LP/J MGP_LPJ_G0023218
 protein coding gene Chr17:23967978-23969114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023130
 protein coding gene Chr17:25259022-25260158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023757
 protein coding gene Chr17:23375423-23376559 (-)
PWK/PhJ MGP_PWKPhJ_G0022287
 protein coding gene Chr17:21353535-21354662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022105
 protein coding gene Chr17:21416346-21417487 (-)
WSB/EiJ MGP_WSBEiJ_G0022601
 protein coding gene Chr17:23441845-23442982 (-)



Homology
more
  • Human Ortholog
    NPW, neuropeptide W
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPW, neuropeptide W
  • Synonyms
    L8, L8C, PPL8, PPNPW
  • Links
    NCBI Gene ID: 283869
    neXtProt AC: NX_Q8N729
    UniProt: Q8N729

  • Chr Location
    16p13.3; chr16:2009926-2020755 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071230 Ensembl Gene Model | MGI Sequence Detail 1128 C57BL/6J ±  kb
transcript ENSMUST00000095544 Ensembl | MGI Sequence Detail 638 Not Applicable  
polypeptide ENSMUSP00000093200 Ensembl | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR013297 Neuropeptide B/W precursor family
    IPR013299 Neuropeptide W precursor
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:248800 Wang R, et al., Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Mol Cell Endocrinol. 2017 May 15;447:71-78
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory