Hecw2 MGI Mouse Gene Detail - MGI:2685817 - HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Symbol

Hecw2
Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms

A730039N16Rik, D030049F17Rik, mKIAA1301, Nedl2

Feature Type

protein coding gene
IDs

MGI:2685817
NCBI Gene: 329152
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr1:53846031-54234193 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.99 cM
Mapping Data

2 experiments

SNPs within 2kb

10079 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685817	protein coding gene	Chr1:53846031-54234327 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016023	protein coding gene	Chr1:53462909-53876182 (-)
A/J	MGP_AJ_G0016006	protein coding gene	Chr1:51609736-51996133 (-)
AKR/J	MGP_AKRJ_G0015962	protein coding gene	Chr1:52998116-53401965 (-)
BALB/cJ	MGP_BALBcJ_G0015961	protein coding gene	Chr1:51656479-52047491 (-)
C3H/HeJ	MGP_C3HHeJ_G0015793	protein coding gene	Chr1:53239164-53637379 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016414	protein coding gene	Chr1:55710298-56115438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014136	protein coding gene	Chr1:47745501-48125469 (-)
CAST/EiJ	MGP_CASTEiJ_G0015375	protein coding gene	Chr1:52510275-52928083 (-)
CBA/J	MGP_CBAJ_G0015765	protein coding gene	Chr1:57262665-57675507 (-)
DBA/2J	MGP_DBA2J_G0015866	protein coding gene	Chr1:51052375-51445598 (-)
FVB/NJ	MGP_FVBNJ_G0015868	protein coding gene	Chr1:50400187-50783737 (-)
LP/J	MGP_LPJ_G0015938	protein coding gene	Chr1:54294527-54699253 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015888	protein coding gene	Chr1:60386045-60797847 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016461	protein coding gene	Chr1:52978149-53388142 (-)
PWK/PhJ	MGP_PWKPhJ_G0015161	protein coding gene	Chr1:50403586-50784184 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014942	protein coding gene	Chr1:52546542-52937424 (-)
WSB/EiJ	MGP_WSBEiJ_G0015438	protein coding gene	Chr1:52662908-53062610 (-)

Human Ortholog

HECW2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HECW2, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms

NDHSAL, NEDL2
Links

HGNC:29853

NCBI Gene ID: 57520

neXtProt AC: NX_Q9P2P5

UniProt: Q9P2P5
Chr Location

2q32.3; chr2:196189099-196593684 (-) GRCh38

MGI Vertebrate Homology

Hecw2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HECW2
Gene Tree

Hecw2

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Hecw2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit postnatal lethality, reduced body weight and size, distended and air-filled intestine, reduced gastric emptying, and hypoplastic myenteric nerve plexus.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

57
RefSeq

14
UniProt

4
CCDS

CCDS14956.1, CCDS14957.1

Ensembl

ENSMUSG00000042807 (Evidence)
NCBI Gene

329152

			Length	Strain/Species	Flank
genomic	329152	NCBI Gene Model \| MGI Sequence Detail	388163	C57BL/6J	± kb
transcript	NM_001001883	RefSeq \| MGI Sequence Detail	11179	Not Specified
polypeptide	Q6I6G8	UniProt \| EBI \| MGI Sequence Detail	1578	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008504 E3 ubiquitin-protein ligase HECW2

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR050409 E3 ubiquitin-protein ligase

IPR032348 E3 ubiquitin-protein ligase HECW1/2, N-terminal

IPR040524 E3 ubiquitin-protein ligase HECW1, helical box domain

IPR037795 E3 ubiquitin-protein ligase HECW, C2 domain

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR001202 WW domain

IPR036020 WW domain superfamily

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All nucleic 8

cDNA 8

Microarray probesets 2

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MGI:2442222

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hecw2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11683	Chr1:54234348-54234370 (-)	-166 bp
Tssr11682	Chr1:54215001-54215008 (-)	19,188 bp
Tssr11680	Chr1:54181877-54181882 (-)	52,313 bp
Tssr11679	Chr1:54017766-54017776 (-)	216,422 bp
Tssr11678	Chr1:54017699-54017743 (-)	216,472 bp
Tssr11677	Chr1:54017670-54017689 (-)	216,513 bp
Tssr11676	Chr1:53953787-53953798 (-)	280,400 bp
Tssr11674	Chr1:53890080-53890121 (-)	344,092 bp
Tssr11673	Chr1:53864226-53864231 (-)	369,964 bp
Tssr11672	Chr1:53864152-53864162 (-)	370,036 bp
Tssr11671	Chr1:53864135-53864146 (-)	370,052 bp
Tssr11670	Chr1:53863104-53863122 (-)	371,080 bp
Tssr11669	Chr1:53863017-53863051 (-)	371,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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