Dnah7a MGI Mouse Gene Detail - MGI:2685838 - dynein, axonemal, heavy chain 7A

Symbol

Dnah7a
Name

dynein, axonemal, heavy chain 7A
Synonyms

Dnahc7, Dnahc7a, LOC381341

Feature Type

protein coding gene
IDs

MGI:2685838
NCBI Gene: 627872
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:53436165-53745943 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.99 cM
Mapping Data

1 experiment

SNPs within 2kb

7685 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685838	protein coding gene	Chr1:53436154-53746456 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015998	protein coding gene	Chr1:45666245-45699092 (+)
A/J	MGP_AJ_G0016004	protein coding gene	Chr1:51484949-51493640 (-)
AKR/J	MGP_AKRJ_G0015960	protein coding gene	Chr1:52840104-52854980 (-)
BALB/cJ	MGP_BALBcJ_G0015937	protein coding gene	Chr1:43409109-43412916 (+)
C3H/HeJ	MGP_C3HHeJ_G0015769	protein coding gene	Chr1:44804851-44833988 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016412	protein coding gene	Chr1:55563354-55573889 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014112	protein coding gene	Chr1:40397283-40406434 (+)
CAST/EiJ	MGP_CASTEiJ_G0015350	protein coding gene	Chr1:44719306-45118834 (+)
CBA/J	MGP_CBAJ_G0015763	protein coding gene	Chr1:57111115-57122754 (-)
DBA/2J	MGP_DBA2J_G0015842	protein coding gene	Chr1:43066570-43069941 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0015936	protein coding gene	Chr1:54147516-54157323 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0016436	protein coding gene	Chr1:44610906-44617658 (+)
PWK/PhJ	MGP_PWKPhJ_G0015134	protein coding gene	Chr1:42926606-42933540 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014940	protein coding gene	Chr1:52234955-52237205 (-)
WSB/EiJ	MGP_WSBEiJ_G0015412	protein coding gene	Chr1:44576665-45004039 (+)

Human Ortholog

DNAH7, dynein axonemal heavy chain 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAH7, dynein axonemal heavy chain 7
Synonyms

CILD50
Links

HGNC:18661

NCBI Gene ID: 56171

neXtProt AC: NX_Q8WXX0

UniProt: Q8WXX0
Chr Location

2q32.3; chr2:195737703-196068837 (-) GRCh38

MGI Vertebrate Homology

Dnah7a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAH7
Gene Tree

Dnah7a

Diseases

1 with human DNAH7 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia IDs primary ciliary dyskinesia DOID:9562 DOID:2925 MESH:D002925 NCI:C84638 OMIM:PS244400 ORDO:244 UMLS_CUI:C0008780

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Genomic Mutations

2 involving Dnah7a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

202 strains or lines available

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

36
RefSeq

9
UniProt

2
CCDS

CCDS56629.1

Ensembl

ENSMUSG00000096141 (Evidence)
NCBI Gene

627872

			Length	Strain/Species	Flank
genomic	ENSMUSG00000096141	Ensembl Gene Model \| MGI Sequence Detail	309779	C57BL/6J	± kb
transcript	ENSMUST00000094964	Ensembl \| MGI Sequence Detail	12245	Not Applicable
polypeptide	ENSMUSP00000092571	Ensembl \| MGI Sequence Detail	4024	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR026983 Dynein heavy chain

IPR041589 Dynein heavy chain 3, AAA+ lid domain

IPR043157 Dynein heavy chain, AAA1 domain, small subdomain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR041658 Dynein heavy chain AAA lid domain

IPR042219 Dynein heavy chain AAA lid domain superfamily

IPR024317 Dynein heavy chain, AAA module D4

IPR035706 Dynein heavy chain, ATP-binding dynein motor region

IPR024743 Dynein heavy chain, coiled coil stalk

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR004273 Dynein heavy chain region D6 P-loop domain

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 4

cDNA 4

Microarray probesets 3

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 6
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:208266 Dong F, et al., Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. J Cell Biol. 2014 Jan 20;204(2):203-13

TSS for Dnah7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11651	Chr1:53745934-53746000 (-)	-24 bp
Tssr11650	Chr1:53588039-53588040 (-)	157,903 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24