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Mamdc4 Gene Detail
Summary
  • Symbol
    Mamdc4
  • Name
    MAM domain containing 4
  • Synonyms
    LOC381352
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685841
    NCBI Gene: 381352
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25453124-25461328 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685841
 protein coding gene Chr2:25453124-25464857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025455
 protein coding gene Chr2:23463895-23475619 (-)
A/J MGP_AJ_G0025432
 protein coding gene Chr2:22550376-22562076 (-)
AKR/J MGP_AKRJ_G0025402
 protein coding gene Chr2:23320167-23331970 (-)
BALB/cJ MGP_BALBcJ_G0025428
 protein coding gene Chr2:22672228-22684029 (-)
C3H/HeJ MGP_C3HHeJ_G0025189
 protein coding gene Chr2:23248398-23261620 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025872
 protein coding gene Chr2:24203423-24215125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023283
 protein coding gene Chr2:21462130-21473987 (-)
CAST/EiJ MGP_CASTEiJ_G0024652
 protein coding gene Chr2:23117389-23129538 (-)
CBA/J MGP_CBAJ_G0025167
 protein coding gene Chr2:25042479-25054087 (-)
DBA/2J MGP_DBA2J_G0025300
 protein coding gene Chr2:22391828-22404326 (-)
FVB/NJ MGP_FVBNJ_G0025262
 protein coding gene Chr2:22139780-22151517 (-)
LP/J MGP_LPJ_G0025386
 protein coding gene Chr2:23401166-23415084 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025293
 protein coding gene Chr2:25238229-25249935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025931
 protein coding gene Chr2:23260205-23272800 (-)
PWK/PhJ MGP_PWKPhJ_G0024400
 protein coding gene Chr2:22213061-22225130 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024200
 protein coding gene Chr2:23405039-23416035 (-)
WSB/EiJ MGP_WSBEiJ_G0024721
 protein coding gene Chr2:23331325-23343052 (-)



Homology
more
  • Human Ortholog
    MAMDC4, MAM domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAMDC4, MAM domain containing 4
  • Synonyms
    AEGP, EDTB
  • Links
    NCBI Gene ID: 158056
    neXtProt AC: NX_Q6UXC1
    UniProt: Q6UXC1

  • Chr Location
    9q34.3; chr9:136850943-136860799 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381352 NCBI Gene Model | MGI Sequence Detail 8205 C57BL/6J ±  kb
transcript NM_001081199 RefSeq | MGI Sequence Detail 3990 C57BL/6  
polypeptide A2AJA7 UniProt | EBI | MGI Sequence Detail 1228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 21
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:322247 Cox CM, et al., The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol. 2018;5(2):145-156
  • Latest
    J:351087 Cox CM, et al., Regulation of YAP and Wnt signaling by the endosomal protein MAMDC4. PLoS One. 2024;19(5):e0296003
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory