Xkr8 MGI Mouse Gene Detail - MGI:2685877 - X-linked Kx blood group related 8

Symbol

Xkr8
Name

X-linked Kx blood group related 8
Synonyms

4931440N07Rik, LOC381560

Feature Type

protein coding gene
IDs

MGI:2685877
NCBI Gene: 381560
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:132452208-132459857 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.81 cM
Mapping Data

2 experiments

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685877	protein coding gene	Chr4:132452208-132459916 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028877	protein coding gene	Chr4:134908352-134916180 (-)
A/J	MGP_AJ_G0028836	protein coding gene	Chr4:129289903-129297802 (-)
AKR/J	MGP_AKRJ_G0028789	protein coding gene	Chr4:132932851-132942707 (-)
BALB/cJ	MGP_BALBcJ_G0028859	protein coding gene	Chr4:129908130-129916324 (-)
C3H/HeJ	MGP_C3HHeJ_G0028573	protein coding gene	Chr4:133195489-133204121 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029301	protein coding gene	Chr4:139779386-139787312 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026572	protein coding gene	Chr4:122364964-122373352 (-)
CAST/EiJ	MGP_CASTEiJ_G0028006	protein coding gene	Chr4:131262245-131269918 (-)
CBA/J	MGP_CBAJ_G0028539	protein coding gene	Chr4:143358208-143366078 (-)
DBA/2J	MGP_DBA2J_G0028688	protein coding gene	Chr4:129708990-129716595 (-)
FVB/NJ	MGP_FVBNJ_G0028655	protein coding gene	Chr4:128568571-128577209 (-)
LP/J	MGP_LPJ_G0028789	protein coding gene	Chr4:135056914-135065168 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028681	protein coding gene	Chr4:147950924-147958777 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029339	protein coding gene	Chr4:133352385-133360995 (-)
PWK/PhJ	MGP_PWKPhJ_G0027727	protein coding gene	Chr4:126405856-126413830 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027553	protein coding gene	Chr4:129193841-129201444 (-)
WSB/EiJ	MGP_WSBEiJ_G0028086	protein coding gene	Chr4:133518726-133528199 (-)

Human Ortholog

XKR8, XK related 8

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XKR8, XK related 8
Synonyms

hXkr8, XRG8
Links

HGNC:25508

NCBI Gene ID: 55113

neXtProt AC: NX_Q9H6D3

UniProt: Q9H6D3
Chr Location

1p35.3; chr1:27959588-27968093 (+) GRCh38

MGI Vertebrate Homology

Xkr8 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: XKR8
Gene Tree

Xkr8

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Xkr8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased testis weight, oligozoospermia, abnormal seminiferous tubule and cauda epididymis morphology, large vacuoles in Sertoli cells, and male infertility caused by inefficient apoptotic testicular germ cell clearance.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xkr8

ZFIN xkr8.3

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS18732.1

Ensembl

ENSMUSG00000037752 (Evidence)
NCBI Gene

381560

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037752	Ensembl Gene Model \| MGI Sequence Detail	7650	C57BL/6J	± kb
transcript	ENSMUST00000045550	Ensembl \| MGI Sequence Detail	4245	Not Applicable
polypeptide	ENSMUSP00000041205	Ensembl \| MGI Sequence Detail	401	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017487 XK-related protein 8

(term hierarchy)
InterPro Domains

IPR050895 XK-related phospholipid scramblase

IPR018629 XK-related protein

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All nucleic 10

cDNA 10

Microarray probesets 4

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MGI:3035048

Summaries

All 40

Gene Ontology 9

Phenotypes 14
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:344898 Chen K, et al., A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy. J Transl Med. 2023 Apr 26;21(1):279

TSS for Xkr8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43698	Chr4:132459876-132459897 (-)	-30 bp
Tssr43697	Chr4:132459825-132459869 (-)	10 bp
Tssr43696	Chr4:132459738-132459749 (-)	113 bp
Tssr43695	Chr4:132459021-132459032 (-)	830 bp
Tssr43694	Chr4:132454938-132454951 (-)	4,912 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24