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Brsk1 Gene Detail
Summary
  • Symbol
    Brsk1
  • Name
    BR serine/threonine kinase 1
  • Synonyms
    LOC381979, SAD-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685946
    NCBI Gene: 381979
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4693635-4718996 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    731 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685946
 protein coding gene Chr7:4693603-4718996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031555
 protein coding gene Chr7:1613662-1643628 (+)
A/J MGP_AJ_G0031529
 protein coding gene Chr7:1622626-1648637 (+)
AKR/J MGP_AKRJ_G0031458
 protein coding gene Chr7:1690314-1717310 (+)
BALB/cJ MGP_BALBcJ_G0031537
 protein coding gene Chr7:1666246-1691642 (+)
C3H/HeJ MGP_C3HHeJ_G0031258
 protein coding gene Chr7:1663511-1691511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031998
 protein coding gene Chr7:1672587-1705707 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029122
 protein coding gene Chr7:1373125-1398061 (+)
CAST/EiJ MGP_CASTEiJ_G0030622
 protein coding gene Chr7:1604241-1631017 (+)
CBA/J MGP_CBAJ_G0031216
 protein coding gene Chr7:1864660-1898174 (+)
DBA/2J MGP_DBA2J_G0031375
 protein coding gene Chr7:1604824-1630501 (+)
FVB/NJ MGP_FVBNJ_G0031327
 protein coding gene Chr7:1570182-1596345 (+)
LP/J MGP_LPJ_G0031460
 protein coding gene Chr7:1726261-1752582 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031366
 protein coding gene Chr7:1811135-1840606 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032028
 protein coding gene Chr7:1600624-1631053 (+)
PWK/PhJ MGP_PWKPhJ_G0030350
 protein coding gene Chr7:1771599-1798537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030175
 protein coding gene Chr7:1649074-1679945 (+)
WSB/EiJ MGP_WSBEiJ_G0030717
 protein coding gene Chr7:1618070-1646175 (+)



Homology
more
  • Human Ortholog
    BRSK1, BR serine/threonine kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRSK1, BR serine/threonine kinase 1
  • Synonyms
    hSAD1, SAD-B
  • Links
    NCBI Gene ID: 84446
    neXtProt AC: NX_Q8TDC3
    UniProt: Q8TDC3

  • Chr Location
    19q13.42; chr19:55282072-55312562 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    13 phenotype references
Homozygous mutant mice are healthy and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    13
  • cDNA Data
    23
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 381979 NCBI Gene Model | MGI Sequence Detail 25362 C57BL/6J ±  kb
transcript NM_001003920 RefSeq | MGI Sequence Detail 3014 C57BL/6  
polypeptide Q5RJI5 UniProt | EBI | MGI Sequence Detail 778 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 1
References
more
  • Summaries
    All 46
    Developmental Gene Expression 8
    Gene Ontology 18
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:330942 Chu Q, et al., STK11 is required for the normal program of ciliated cell differentiation in airways. Cell Discov. 2019;5:36
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory