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Cib3 Gene Detail
Summary
  • Symbol
    Cib3
  • Name
    calcium and integrin binding family member 3
  • Synonyms
    C730014M21Rik, KIP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685953
    NCBI Gene: 234421
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:72958179-72966840 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685953
 protein coding gene Chr8:72958179-72966892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033775
 protein coding gene Chr8:72688835-72697449 (-)
A/J MGP_AJ_G0033758
 protein coding gene Chr8:69754161-69762657 (-)
AKR/J MGP_AKRJ_G0033684
 protein coding gene Chr8:71817006-71825629 (-)
BALB/cJ MGP_BALBcJ_G0033752
 protein coding gene Chr8:69881820-69890434 (-)
C3H/HeJ MGP_C3HHeJ_G0033461
 protein coding gene Chr8:72440088-72448704 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034272
 protein coding gene Chr8:75434364-75442968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031213
 protein coding gene Chr8:64270297-64278933 (-)
CAST/EiJ MGP_CASTEiJ_G0032789
 protein coding gene Chr8:71791175-71799575 (-)
CBA/J MGP_CBAJ_G0033440
 protein coding gene Chr8:78128304-78136918 (-)
DBA/2J MGP_DBA2J_G0033594
 protein coding gene Chr8:69493349-69501963 (-)
FVB/NJ MGP_FVBNJ_G0033539
 protein coding gene Chr8:68567706-68576256 (-)
LP/J MGP_LPJ_G0033683
 protein coding gene Chr8:72781935-72791480 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033583
 protein coding gene Chr8:80635170-80643660 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034289
 protein coding gene Chr8:71838081-71846793 (-)
PWK/PhJ MGP_PWKPhJ_G0032496
 protein coding gene Chr8:68752982-68761928 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032333
 protein coding gene Chr8:70803933-70812343 (-)
WSB/EiJ MGP_WSBEiJ_G0032904
 protein coding gene Chr8:72181411-72190021 (-)



Homology
more
  • Human Ortholog
    CIB3, calcium and integrin binding family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIB3, calcium and integrin binding family member 3
  • Synonyms
    KIP3
  • Links
    NCBI Gene ID: 117286
    neXtProt AC: NX_Q96Q77
    UniProt: Q96Q77

  • Chr Location
    19p13.11; chr19:16161368-16173525 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired balance with age and vestibular hair cell loss with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074240 Ensembl Gene Model | MGI Sequence Detail 8662 C57BL/6J ±  kb
    transcript ENSMUST00000238973 Ensembl | MGI Sequence Detail 617 Not Applicable  
    polypeptide ENSMUSP00000159168 Ensembl | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:142018 Hager M, et al., Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. J Biol Chem. 2008 Sep 5;283(36):24760-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory