Adgrg5 MGI Mouse Gene Detail - MGI:2685955 - adhesion G protein-coupled receptor G5

Symbol

Adgrg5
Name

adhesion G protein-coupled receptor G5
Synonyms

Gpr114, LOC382045, PGR27

Feature Type

protein coding gene
IDs

MGI:2685955
NCBI Gene: 382045
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:95650322-95669908 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 47.03 cM
Mapping Data

2 experiments

SNPs within 2kb

722 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685955	protein coding gene	Chr8:95648439-95669921 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033975	protein coding gene	Chr8:96367368-96389215 (+)
A/J	MGP_AJ_G0033958	protein coding gene	Chr8:92612923-92632685 (+)
AKR/J	MGP_AKRJ_G0033884	protein coding gene	Chr8:95138415-95158119 (+)
BALB/cJ	MGP_BALBcJ_G0033950	protein coding gene	Chr8:92693967-92714194 (+)
C3H/HeJ	MGP_C3HHeJ_G0033660	protein coding gene	Chr8:95852593-95874710 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034471	protein coding gene	Chr8:99886271-99906478 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031412	protein coding gene	Chr8:86415002-86434695 (+)
CAST/EiJ	MGP_CASTEiJ_G0032992	protein coding gene	Chr8:95453534-95477537 (+)
CBA/J	MGP_CBAJ_G0033636	protein coding gene	Chr8:103176543-103200192 (+)
DBA/2J	MGP_DBA2J_G0033790	protein coding gene	Chr8:92092245-92117499 (+)
FVB/NJ	MGP_FVBNJ_G0033737	protein coding gene	Chr8:91042993-91064057 (+)
LP/J	MGP_LPJ_G0033882	protein coding gene	Chr8:96515040-96535565 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033779	protein coding gene	Chr8:105462439-105483160 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034489	protein coding gene	Chr8:95296587-95324222 (+)
PWK/PhJ	MGP_PWKPhJ_G0032694	protein coding gene	Chr8:91459873-91479562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032531	protein coding gene	Chr8:94144372-94172294 (+)
WSB/EiJ	MGP_WSBEiJ_G0033104	protein coding gene	Chr8:95836147-95858032 (+)

Human Ortholog

ADGRG5, adhesion G protein-coupled receptor G5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRG5, adhesion G protein-coupled receptor G5
Synonyms

GPR114, PGR27
Links

HGNC:19010

NCBI Gene ID: 221188

neXtProt AC: NX_Q8IZF4

UniProt: Q8IZF4
Chr Location

16q21; chr16:57529073-57591681 (+) GRCh38

MGI Vertebrate Homology

Adgrg5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRG5
Gene Tree

Adgrg5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

56
RefSeq

14
UniProt

4
CCDS

CCDS22552.1, CCDS52637.1

Ensembl

ENSMUSG00000061577 (Evidence)
NCBI Gene

382045

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061577	Ensembl Gene Model \| MGI Sequence Detail	19587	C57BL/6J	± kb
transcript	ENSMUST00000166802	Ensembl \| MGI Sequence Detail	1879	Not Applicable
polypeptide	ENSMUSP00000132628	Ensembl \| MGI Sequence Detail	524	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031936 adhesion G-protein coupled receptor G5

(term hierarchy)
InterPro Domains

IPR046338 GAIN domain superfamily

IPR017981 GPCR, family 2-like, 7TM

IPR003910 GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5

IPR000832 GPCR, family 2, secretin-like

IPR000203 GPS motif
GlyGen

Q3V3Z3 8 sites

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 11
Earliest

J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adgrg5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78923	Chr8:95650178-95650210 (+)	-128 bp
Tssr78924	Chr8:95650302-95650311 (+)	-15 bp
Tssr78925	Chr8:95650315-95650336 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24