Zfp488 MGI Mouse Gene Detail - MGI:2686052

Symbol

Zfp488
Name

zinc finger protein 488
Synonyms

LOC382867

Feature Type

protein coding gene
IDs

MGI:2686052
NCBI Gene: 382867
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:33689027-33700721 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.80 cM
Mapping Data

1 experiment

SNPs within 2kb

421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2686052	protein coding gene	Chr14:33689023-33700986 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021162	protein coding gene	Chr14:27299268-27311970 (-)
A/J	MGP_AJ_G0021110	protein coding gene	Chr14:26244317-26255280 (-)
AKR/J	MGP_AKRJ_G0021087	protein coding gene	Chr14:27412664-27423632 (-)
BALB/cJ	MGP_BALBcJ_G0021114	protein coding gene	Chr14:26428500-26440112 (-)
C3H/HeJ	MGP_C3HHeJ_G0020897	protein coding gene	Chr14:27329007-27340625 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021546	protein coding gene	Chr14:28347931-28360521 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019108	protein coding gene	Chr14:26282101-26292971 (-)
CAST/EiJ	MGP_CASTEiJ_G0020422	protein coding gene	Chr14:27144765-27157278 (-)
CBA/J	MGP_CBAJ_G0020864	protein coding gene	Chr14:29381480-29398871 (-)
DBA/2J	MGP_DBA2J_G0020986	protein coding gene	Chr14:26282151-26293195 (-)
FVB/NJ	MGP_FVBNJ_G0020970	protein coding gene	Chr14:26236090-26249001 (-)
LP/J	MGP_LPJ_G0021055	protein coding gene	Chr14:27636417-27648023 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020996	protein coding gene	Chr14:28538035-28548980 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021579	protein coding gene	Chr14:27238528-27249520 (-)
PWK/PhJ	MGP_PWKPhJ_G0020170	protein coding gene	Chr14:25772847-25784368 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019994	protein coding gene	Chr14:26857327-26868009 (-)
WSB/EiJ	MGP_WSBEiJ_G0020477	protein coding gene	Chr14:27302459-27314341 (-)

Human Ortholog

ZNF488, zinc finger protein 488

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF488, zinc finger protein 488
Links

HGNC:23535

NCBI Gene ID: 118738

neXtProt AC: NX_Q96MN9

UniProt: Q96MN9
Chr Location

10q11.22; chr10:47365496-47384293 (-) GRCh38

MGI Vertebrate Homology

Zfp488 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF488
Gene Tree

Zfp488

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

20
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

12
UniProt

1
CCDS

CCDS26930.2

Ensembl

ENSMUSG00000044519 (Evidence)
NCBI Gene

382867

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044519	Ensembl Gene Model \| MGI Sequence Detail	11695	C57BL/6J	± kb
transcript	ENSMUST00000166737	Ensembl \| MGI Sequence Detail	4301	Not Applicable
polypeptide	ENSMUSP00000132436	Ensembl \| MGI Sequence Detail	337	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017927 zinc finger protein 488

(term hierarchy)
InterPro Domains

IPR052296 Transcriptional Repressor and Histone Methyltransferase

IPR013087 Zinc finger C2H2-type

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All nucleic 8

cDNA 7

Other 1

Microarray probesets 1

Summaries

All 22

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 3
Earliest

J:112231 Wang SZ, et al., An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Development. 2006 Sep;133(17):3389-98
Latest

J:350808 Schmidt AL, et al., The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. Glia. 2024 Jul;72(7):1304-1318

TSS for Zfp488:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128043	Chr14:33700758-33700769 (-)	-43 bp
Tssr128042	Chr14:33700708-33700748 (-)	-7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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