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Slc25a34 Gene Detail
Summary
  • Symbol
    Slc25a34
  • Name
    solute carrier family 25, member 34
  • Synonyms
    LOC384071
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686215
    NCBI Gene: 384071
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141346135-141351132 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686215
 protein coding gene Chr4:141346130-141351202 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029052
 protein coding gene Chr4:144702029-144706882 (-)
A/J MGP_AJ_G0029012
 protein coding gene Chr4:138393935-138398761 (-)
AKR/J MGP_AKRJ_G0028964
 protein coding gene Chr4:142413283-142420178 (-)
BALB/cJ MGP_BALBcJ_G0029036
 protein coding gene Chr4:139087702-139093604 (-)
C3H/HeJ MGP_C3HHeJ_G0028750
 protein coding gene Chr4:142780048-142784912 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029477
 protein coding gene Chr4:149736817-149741596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026748
 protein coding gene Chr4:131306299-131311147 (-)
CAST/EiJ MGP_CASTEiJ_G0028182
 protein coding gene Chr4:141051885-141058186 (-)
CBA/J MGP_CBAJ_G0028714
 protein coding gene Chr4:154135109-154145657 (-)
DBA/2J MGP_DBA2J_G0028864
 protein coding gene Chr4:138790683-138795471 (-)
FVB/NJ MGP_FVBNJ_G0028831
 protein coding gene Chr4:137910211-137915019 (-)
LP/J MGP_LPJ_G0028963
 protein coding gene Chr4:144722579-144728734 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028857
 protein coding gene Chr4:157894706-157900522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029515
 protein coding gene Chr4:142929693-142935041 (-)
PWK/PhJ MGP_PWKPhJ_G0027903
 protein coding gene Chr4:135682117-135687305 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027727
 protein coding gene Chr4:138740593-138745579 (-)
WSB/EiJ MGP_WSBEiJ_G0028260
 protein coding gene Chr4:143208806-143213648 (-)



Homology
more
  • Human Ortholog
    SLC25A34, solute carrier family 25 member 34
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A34, solute carrier family 25 member 34
  • Links
    NCBI Gene ID: 284723
    neXtProt AC: NX_Q6PIV7
    UniProt: Q6PIV7

  • Chr Location
    1p36.21; chr1:15736258-15741392 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in the liver display abnormalities in lipogenesis and glucose homeostasis on a fast food diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040740 Ensembl Gene Model | MGI Sequence Detail 4998 C57BL/6J ±  kb
    transcript ENSMUST00000038661 Ensembl | MGI Sequence Detail 2670 Not Applicable  
    polypeptide ENSMUSP00000039188 Ensembl | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:344152 Roy N, et al., Dysregulation of Lipid and Glucose Homeostasis in Hepatocyte-Specific SLC25A34 Knockout Mice. Am J Pathol. 2022 Sep;192(9):1259-1281
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory