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Prob1 Gene Detail
Summary
  • Symbol
    Prob1
  • Name
    proline rich basic protein 1
  • Synonyms
    Gm1614, LOC381148
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686460
    NCBI Gene: 381148
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35783400-35788274 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686460
 protein coding gene Chr18:35783400-35788291 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024265
 protein coding gene Chr18:33970721-33975608 (-)
A/J MGP_AJ_G0024231
 protein coding gene Chr18:32803656-32808543 (-)
AKR/J MGP_AKRJ_G0024199
 protein coding gene Chr18:33726930-33731817 (-)
BALB/cJ MGP_BALBcJ_G0024231
 protein coding gene Chr18:32848340-32853227 (-)
C3H/HeJ MGP_C3HHeJ_G0023998
 protein coding gene Chr18:33753380-33758267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024672
 protein coding gene Chr18:35192074-35196961 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022112
 protein coding gene Chr18:32907957-32912855 (-)
CAST/EiJ MGP_CASTEiJ_G0023473
 protein coding gene Chr18:33740479-33745363 (-)
CBA/J MGP_CBAJ_G0023966
 protein coding gene Chr18:36203473-36208360 (-)
DBA/2J MGP_DBA2J_G0024098
 protein coding gene Chr18:32435597-32440484 (-)
FVB/NJ MGP_FVBNJ_G0024065
 protein coding gene Chr18:32121717-32126604 (-)
LP/J MGP_LPJ_G0024180
 protein coding gene Chr18:34025819-34030706 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024093
 protein coding gene Chr18:37441043-37445930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024721
 protein coding gene Chr18:33564766-33569653 (-)
PWK/PhJ MGP_PWKPhJ_G0023217
 protein coding gene Chr18:32659163-32664047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023024
 protein coding gene Chr18:33828166-33833070 (-)
WSB/EiJ MGP_WSBEiJ_G0023536
 protein coding gene Chr18:33485267-33490154 (-)



Homology
more
  • Human Ortholog
    PROB1, proline rich basic protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PROB1, proline rich basic protein 1
  • Synonyms
    C5orf65
  • Links
    NCBI Gene ID: 389333
    neXtProt AC: NX_E7EW31
    UniProt: E7EW31

  • Chr Location
    5q31.2; chr5:139390592-139395104 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381148 NCBI Gene Model | MGI Sequence Detail 4875 C57BL/6J ±  kb
    transcript NM_001270646 RefSeq | MGI Sequence Detail 4875 C57BL/6  
    polypeptide NP_001257575 RefSeq | MGI Sequence Detail 1010 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR052303 Cardiac-enriched FHL2-interacting
      IPR027838 Domain of unknown function DUF4585
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory