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Nicol1 Gene Detail
Summary
  • Symbol
    Nicol1
  • Name
    NELL2 interacting cell ontogeny regulator 1
  • Synonyms
    Gm1673, LOC381633
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686519
    NCBI Gene: 381633
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34140863-34142353 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686519
 protein coding gene Chr5:34140777-34142357 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029456
 protein coding gene Chr5:32185837-32187417 (+)
A/J MGP_AJ_G0029423
 protein coding gene Chr5:31133510-31135100 (+)
AKR/J MGP_AKRJ_G0029372
 protein coding gene Chr5:32334499-32336089 (+)
BALB/cJ MGP_BALBcJ_G0029433
 protein coding gene Chr5:31659996-31661586 (+)
C3H/HeJ MGP_C3HHeJ_G0029155
 protein coding gene Chr5:32367882-32369472 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029887
 protein coding gene Chr5:34072464-34074044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027124
 protein coding gene Chr5:28930381-28931955 (+)
CAST/EiJ MGP_CASTEiJ_G0028564
 protein coding gene Chr5:31449919-31451509 (+)
CBA/J MGP_CBAJ_G0029123
 protein coding gene Chr5:34799689-34801279 (+)
DBA/2J MGP_DBA2J_G0029271
 protein coding gene Chr5:31316378-31317968 (+)
FVB/NJ MGP_FVBNJ_G0029230
 protein coding gene Chr5:30743987-30745567 (+)
LP/J MGP_LPJ_G0029356
 protein coding gene Chr5:32607401-32608981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029260
 protein coding gene Chr5:35675052-35676632 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029920
 protein coding gene Chr5:31851373-31852953 (+)
PWK/PhJ MGP_PWKPhJ_G0028289
 protein coding gene Chr5:30447942-30449522 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028120
 protein coding gene Chr5:31306958-31308551 (+)
WSB/EiJ MGP_WSBEiJ_G0028645
 protein coding gene Chr5:31925394-31926984 (+)



Homology
more
  • Human Ortholog
    NICOL1, NELL2 interacting cell ontogeny regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NICOL1, NELL2 interacting cell ontogeny regulator 1
  • Synonyms
    C4orf48, CHR4_55, NICOL
  • Links
    NCBI Gene ID: 401115
    UniProt: Q5BLP8

  • Chr Location
    4p16.3; chr4:2036554-2043964 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility with epididymis degeneration, impaired sperm migration in female genital tract, impaired binding of sperm to zona pellucida, and decreased fertilization frequency.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381633 NCBI Gene Model | MGI Sequence Detail 1491 C57BL/6J ±  kb
    transcript NM_001310547 RefSeq | MGI Sequence Detail 466 C57BL/6  
    polypeptide Q3UR78 UniProt | EBI | MGI Sequence Detail 90 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000033622 NELL2-interacting cell ontogeny regulator 1
      (term hierarchy)
    • InterPro Domains
      IPR028147 NELL2-interacting cofactor for lumicrine signalling
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:7524430
    References
    more
    • Summaries
      All 46
      Diseases 1
      Gene Ontology 3
      Phenotypes 30
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:349399 Yang J, et al., The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism. J Clin Invest. 2024 Apr 16;134(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory