About   Help   FAQ
Ighg2c Gene Detail
Summary
  • Symbol
    Ighg2c
  • Name
    immunoglobulin heavy constant gamma 2C
  • Feature Type
    gene segment
  • IDs
    MGI:2686979
    NCBI Gene: 404711
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113251009-113252552 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686979
 gene segment Chr12:113248945-113252552 (-)
129S1/SvImJ MGP_129S1SvImJ_G0000005
 gene segment Chr12:115822114-115823632 (-)
A/J MGP_AJ_G0000005
 gene segment Chr12:111311792-111317992 (-)
AKR/J MGP_AKRJ_G0000005
 gene segment Chr12:114566280-114573076 (-)
BALB/cJ MGP_BALBcJ_G0000005
 gene segment Chr12:111781904-111783530 (-)
C3H/HeJ MGP_C3HHeJ_G0000005
 gene segment Chr12:115063518-115065144 (-)
C57BL/6NJ MGP_C57BL6NJ_G0000005
 gene segment Chr12:119337741-119341348 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0000005
 gene segment Chr12:123932299-123933925 (-)
DBA/2J MGP_DBA2J_G0000005
 gene segment Chr12:110832288-110833918 (-)
FVB/NJ MGP_FVBNJ_G0000005
 gene segment Chr12:109660784-109662408 (-)
LP/J MGP_LPJ_G0000005
 gene segment Chr12:115634859-115636506 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0000005
 gene segment Chr12:114070857-114072483 (-)
PWK/PhJ MGP_PWKPhJ_G0000006
 gene segment Chr12:105508570-105510110 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0000006
 gene segment Chr12:115032346-115033886 (-)



Homology
more
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
  • Links
    NCBI Gene ID: 3500
    UniProt: P01857

  • Chr Location
    14q32.33; chr14:105736343-105743071 (-)  GRCh38
  • Human Ortholog
    IGHG2, immunoglobulin heavy constant gamma 2 (G2m marker)
  • Links
    NCBI Gene ID: 3501
    UniProt: P01859

  • Chr Location
    14q32.33; chr14:105639559-105644790 (-)  GRCh38
  • Human Ortholog
    IGHG3, immunoglobulin heavy constant gamma 3 (G3m marker)
  • Synonyms
    IgG3
  • Links
    NCBI Gene ID: 3502
    UniProt: P01860

  • Chr Location
    14q32.33; chr14:105764503-105771405 (-)  GRCh38
  • Human Ortholog
    IGHG4, immunoglobulin heavy constant gamma 4 (G4m marker)
  • Links
    NCBI Gene ID: 3503
    UniProt: P01861

  • Chr Location
    14q32.33; chr14:105620506-105626066 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a G400R mutation show reduced tumorigenesis in colon carcinoma models with increased tumor-associated antigen-specific IgG2c antibodies and antibody-dependent tumor cell phagocytosis. Mice with a truncation in the cytoplasmic tail of the membrane-bound Ighg2c heavy chain show increased tumorigenesis in colon carcinoma models.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 404711 NCBI Gene Model | MGI Sequence Detail 1544 C57BL/6J ±  kb
    polypeptide F6TQW2 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR050380 Immune Recognition and Response Modulators
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    • GlyGen
      F6TQW2 1 site, 2 N-linked glycans (1 site)
    Molecular
    Reagents
    less
    • All nucleic 1
      Genomic 1
    References
    more
    • Summaries
      All 33
      Gene Ontology 8
      Phenotypes 1
    • Earliest
      J:5559 Taylor BA, et al., Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature. 1975 Aug 21;256(5519):644-6
    • Latest
      J:322180 Yang B, et al., An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. J Clin Invest. 2022 Mar 15;132(6):e153454
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory