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Leprot Gene Detail
Summary
  • Symbol
    Leprot
  • Name
    leptin receptor overlapping transcript
  • Synonyms
    Endo1`, Endospanin1, Obrgrp, OB-RGRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687005
    NCBI Gene: 230514
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:101504922-101516561 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 46.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687005
 protein coding gene Chr4:101504915-101516561 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028494
 protein coding gene Chr4:101964856-101977509 (+)
A/J MGP_AJ_G0028457
 protein coding gene Chr4:98398688-98410344 (+)
AKR/J MGP_AKRJ_G0028404
 protein coding gene Chr4:100778235-100791468 (+)
BALB/cJ MGP_BALBcJ_G0028475
 protein coding gene Chr4:98615006-98626704 (+)
C3H/HeJ MGP_C3HHeJ_G0028188
 protein coding gene Chr4:101578272-101594734 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028914
 protein coding gene Chr4:105813535-105825088 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026206
 protein coding gene Chr4:93667595-93679267 (+)
CAST/EiJ MGP_CASTEiJ_G0027628
 protein coding gene Chr4:99367303-99381348 (+)
CBA/J MGP_CBAJ_G0028157
 protein coding gene Chr4:109140983-109157485 (+)
DBA/2J MGP_DBA2J_G0028307
 protein coding gene Chr4:98093231-98105105 (+)
FVB/NJ MGP_FVBNJ_G0028274
 protein coding gene Chr4:96932052-96944313 (+)
LP/J MGP_LPJ_G0028407
 protein coding gene Chr4:102270140-102282519 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028302
 protein coding gene Chr4:114674542-114688095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028952
 protein coding gene Chr4:101037837-101050270 (+)
PWK/PhJ MGP_PWKPhJ_G0027353
 protein coding gene Chr4:96267149-96279016 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027175
 protein coding gene Chr4:98484618-98496285 (+)
WSB/EiJ MGP_WSBEiJ_G0027706
 protein coding gene Chr4:101198908-101211301 (+)



Homology
more
  • Human Ortholog
    LEPROT, leptin receptor overlapping transcript
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEPROT, leptin receptor overlapping transcript
  • Synonyms
    LEPR, OB-RGRP, OBRGRP, VPS55
  • Links
    NCBI Gene ID: 54741
    neXtProt AC: NX_O15243
    UniProt: O15243

  • Chr Location
    1p31.3; chr1:65420587-65436007 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show reduced food intake and on a high fat diet show altered fat distribution and improved glucose tolerance and insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    8
  • cDNA Data
    111
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230514 NCBI Gene Model | MGI Sequence Detail 11640 C57BL/6J ±  kb
    transcript NR_185080 RefSeq | MGI Sequence Detail 1999 C57BL/6  
    polypeptide O89013 UniProt | EBI | MGI Sequence Detail 131 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 5
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:38995 Micallef MJ, et al., In vivo antitumor effects of murine interferon-gamma-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol Immunother. 1997 Jan;43(6):361-7
    • Latest
      J:349250 Roca-Rivada A, et al., Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations. JCI Insight. 2024 Apr 2;9(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory