Pfkfb4 MGI Mouse Gene Detail - MGI:2687284 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Symbol

Pfkfb4
Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Feature Type

protein coding gene
IDs

MGI:2687284
NCBI Gene: 270198
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:108820846-108861296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.63 cM
Mapping Data

1 experiment

SNPs within 2kb

1198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687284	protein coding gene	Chr9:108817336-108861302 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035320	protein coding gene	Chr9:110939210-110988761 (+)
A/J	MGP_AJ_G0035299	protein coding gene	Chr9:106871578-106910012 (+)
AKR/J	MGP_AKRJ_G0035231	protein coding gene	Chr9:109553261-109595914 (+)
BALB/cJ	MGP_BALBcJ_G0035293	protein coding gene	Chr9:106567075-106610618 (+)
C3H/HeJ	MGP_C3HHeJ_G0035003	protein coding gene	Chr9:109949667-109994078 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035813	protein coding gene	Chr9:113972778-114014137 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032711	protein coding gene	Chr9:104276976-104315998 (+)
CAST/EiJ	MGP_CASTEiJ_G0034314	protein coding gene	Chr9:109924660-109965173 (+)
CBA/J	MGP_CBAJ_G0034971	protein coding gene	Chr9:117983688-118029514 (+)
DBA/2J	MGP_DBA2J_G0035132	protein coding gene	Chr9:106322227-106363034 (+)
FVB/NJ	MGP_FVBNJ_G0035080	protein coding gene	Chr9:105141545-105181915 (+)
LP/J	MGP_LPJ_G0035208	protein coding gene	Chr9:111130063-111174236 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035119	protein coding gene	Chr9:119539152-119581377 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035834	protein coding gene	Chr9:109826513-109868172 (+)
PWK/PhJ	MGP_PWKPhJ_G0034021	protein coding gene	Chr9:106658818-106697684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033856	protein coding gene	Chr9:109896271-109935529 (+)
WSB/EiJ	MGP_WSBEiJ_G0034435	protein coding gene	Chr9:109725832-109768867 (+)

Human Ortholog

PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Links

HGNC:8875

NCBI Gene ID: 5210

neXtProt AC: NX_Q16877

UniProt: Q16877
Chr Location

3p21.31; chr3:48517684-48563136 (-) GRCh38

MGI Vertebrate Homology

Pfkfb4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PFKFB4
Protein SuperFamily

6PFK_2-Ptase
Gene Tree

Pfkfb4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

153
cDNA Data

30
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pfkfb4

ZFIN pfkfb4a, pfkfb4b

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All Sequences

88
RefSeq

30
UniProt

7
CCDS

CCDS23541.1

Ensembl

ENSMUSG00000025648 (Evidence)
NCBI Gene

270198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025648	Ensembl Gene Model \| MGI Sequence Detail	40451	C57BL/6J	± kb
transcript	ENSMUST00000198140	Ensembl \| MGI Sequence Detail	3488	Not Applicable
polypeptide	ENSMUSP00000142378	Ensembl \| MGI Sequence Detail	469	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012581 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

(term hierarchy)
EC

2.7.1.105, 3.1.3.46
InterPro Domains

IPR013079 6-phosphofructo-2-kinase

IPR003094 Fructose-2,6-bisphosphatase

IPR029033 Histidine phosphatase superfamily

IPR013078 Histidine phosphatase superfamily, clade-1

IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 32

cDNA 31

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pfkfb4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87188	Chr9:108818905-108818917 (+)	-1,935 bp
Tssr87189	Chr9:108818996-108819026 (+)	-1,835 bp
Tssr87190	Chr9:108821020-108821037 (+)	183 bp
Tssr87191	Chr9:108821050-108821070 (+)	214 bp
Tssr87192	Chr9:108836612-108836655 (+)	15,788 bp
Tssr87193	Chr9:108836952-108836984 (+)	16,122 bp
Tssr87194	Chr9:108846440-108846466 (+)	25,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24