Ano8 MGI Mouse Gene Detail - MGI:2687327

Symbol

Ano8
Name

anoctamin 8
Synonyms

Tmem16h

Feature Type

protein coding gene
IDs

MGI:2687327
NCBI Gene: 382014
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:71928663-71938607 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

1 experiment

SNPs within 2kb

198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687327	protein coding gene	Chr8:71928660-71938735 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033748	protein coding gene	Chr8:71871450-71883241 (-)
A/J	MGP_AJ_G0033731	protein coding gene	Chr8:68947172-68957217 (-)
AKR/J	MGP_AKRJ_G0033656	protein coding gene	Chr8:70978907-70988979 (-)
BALB/cJ	MGP_BALBcJ_G0033727	protein coding gene	Chr8:69118402-69128286 (-)
C3H/HeJ	MGP_C3HHeJ_G0033437	protein coding gene	Chr8:71558551-71569768 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034245	protein coding gene	Chr8:74614900-74624718 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031187	protein coding gene	Chr8:63587540-63597409 (-)
CAST/EiJ	MGP_CASTEiJ_G0032762	protein coding gene	Chr8:71023052-71033106 (-)
CBA/J	MGP_CBAJ_G0033415	protein coding gene	Chr8:77252730-77267116 (-)
DBA/2J	MGP_DBA2J_G0033569	protein coding gene	Chr8:68678122-68688233 (-)
FVB/NJ	MGP_FVBNJ_G0033511	protein coding gene	Chr8:67757239-67768130 (-)
LP/J	MGP_LPJ_G0033656	protein coding gene	Chr8:71848979-71859908 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033558	protein coding gene	Chr8:79807749-79819134 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034262	protein coding gene	Chr8:71043444-71053391 (-)
PWK/PhJ	MGP_PWKPhJ_G0032469	protein coding gene	Chr8:67953263-67963640 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032306	protein coding gene	Chr8:69990410-70000453 (-)
WSB/EiJ	MGP_WSBEiJ_G0032877	protein coding gene	Chr8:71391667-71403036 (-)

Human Ortholog

ANO8, anoctamin 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANO8, anoctamin 8
Synonyms

KIAA1623, TMEM16H
Links

HGNC:29329

NCBI Gene ID: 57719

neXtProt AC: NX_Q9HCE9

UniProt: Q9HCE9
Chr Location

19p13.11; chr19:17323223-17334855 (-) GRCh38

MGI Vertebrate Homology

Ano8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ANO8
Gene Tree

Ano8

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Ano8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

59
cDNA Data

5
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ano8

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All Sequences

55
RefSeq

18
UniProt

2
CCDS

CCDS52585.1

Ensembl

ENSMUSG00000034863 (Evidence)
NCBI Gene

382014

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034863	Ensembl Gene Model \| MGI Sequence Detail	9945	C57BL/6J	± kb
transcript	ENSMUST00000213382	Ensembl \| MGI Sequence Detail	3785	Not Applicable
polypeptide	ENSMUSP00000149365	Ensembl \| MGI Sequence Detail	1104	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004063 anoctamin-8

(term hierarchy)
InterPro Domains

IPR007632 Anoctamin

IPR049452 Anoctamin, transmembrane domain
GlyGen

Q6PB70 1 site

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 27

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 6
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ano8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81716	Chr8:71938976-71938983 (-)	-373 bp
Tssr81715	Chr8:71938681-71938700 (-)	-84 bp
Tssr81714	Chr8:71938641-71938679 (-)	-53 bp
Tssr81713	Chr8:71938598-71938625 (-)	-5 bp
Tssr81712	Chr8:71938572-71938587 (-)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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