Scn4b MGI Mouse Gene Detail - MGI:2687406 - sodium channel, type IV, beta

Symbol

Scn4b
Name

sodium channel, type IV, beta
Synonyms

LOC384934

Feature Type

protein coding gene
IDs

MGI:2687406
NCBI Gene: 399548
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr9:45049922-45065453 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

2 experiments

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2687406	protein coding gene	Chr9:45049693-45065453 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034732	protein coding gene	Chr9:43684498-43700245 (+)
A/J	MGP_AJ_G0034713	protein coding gene	Chr9:42464740-42480538 (+)
AKR/J	MGP_AKRJ_G0034640	protein coding gene	Chr9:43338877-43354585 (+)
BALB/cJ	MGP_BALBcJ_G0034704	protein coding gene	Chr9:42198133-42213839 (+)
C3H/HeJ	MGP_C3HHeJ_G0034415	protein coding gene	Chr9:43795703-43811426 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035225	protein coding gene	Chr9:44961164-44979063 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032139	protein coding gene	Chr9:42018602-42034861 (+)
CAST/EiJ	MGP_CASTEiJ_G0033737	protein coding gene	Chr9:43655091-43671398 (+)
CBA/J	MGP_CBAJ_G0034387	protein coding gene	Chr9:46611432-46630091 (+)
DBA/2J	MGP_DBA2J_G0034546	protein coding gene	Chr9:42353004-42370119 (+)
FVB/NJ	MGP_FVBNJ_G0034487	protein coding gene	Chr9:41610290-41625995 (+)
LP/J	MGP_LPJ_G0034627	protein coding gene	Chr9:43981727-43997480 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034531	protein coding gene	Chr9:48432921-48448633 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035246	protein coding gene	Chr9:43258994-43274712 (+)
PWK/PhJ	MGP_PWKPhJ_G0033442	protein coding gene	Chr9:42240524-42256434 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033278	protein coding gene	Chr9:43550663-43566467 (+)
WSB/EiJ	MGP_WSBEiJ_G0033850	protein coding gene	Chr9:43288463-43304184 (+)

Human Ortholog

SCN4B, sodium voltage-gated channel beta subunit 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCN4B, sodium voltage-gated channel beta subunit 4
Synonyms

ATFB17, LQT10, Navbeta4
Links

HGNC:10592

NCBI Gene ID: 6330

neXtProt AC: NX_Q8IWT1

UniProt: Q8IWT1
Chr Location

11q23.3; chr11:118133377-118152888 (-) GRCh38

MGI Vertebrate Homology

Scn4b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SCN4B
Gene Tree

Scn4b

Diseases

1 with human SCN4B associations

				Human Disease	Mouse Models
				long QT syndrome 10 IDs long QT syndrome 10 DOID:0110651 ICD10CM:I45.8 MESH:C567514 OMIM:611819

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

19 strains or lines available

Homozygous null mice exhibit depolarizing shifts in action potential thresholds in core accumbens medium spiny neurons, and reduced ability to induce spike-timing-dependent long-term depression (tLTD). Amphetamine-induced locomotor activity is reduced in male mutant mice.

less

All GO Annotations

45
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

7
cDNA Data

9
Literature Summary

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scn4b

ZFIN scn4ba, scn4bb

less

All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS23130.1

Ensembl

ENSMUSG00000046480 (Evidence)
NCBI Gene

399548

			Length	Strain/Species	Flank
genomic	399548	NCBI Gene Model \| MGI Sequence Detail	15532	C57BL/6J	± kb
transcript	NM_001013390	RefSeq \| MGI Sequence Detail	4771	C57BL/6
polypeptide	Q7M729	UniProt \| EBI \| MGI Sequence Detail	228	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000014525 sodium channel subunit beta-4

(term hierarchy)
PDB

5AYQ, 5XAX
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

IPR000920 Myelin P0 protein-related
GlyGen

Q7M729 5 sites, 10 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

less

All nucleic 12

Genomic 2

cDNA 9

Primer pair 1

Microarray probesets 2

less

MGI:2686317

Summaries

All 41

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 8
Earliest

J:98459 Grieco TM, et al., Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 2005 Jan 20;45(2):233-44
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Scn4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84734	Chr9:45049594-45049603 (+)	-323 bp
Tssr84735	Chr9:45049612-45049619 (+)	-306 bp
Tssr84736	Chr9:45049688-45049701 (+)	-227 bp
Tssr84737	Chr9:45049755-45049760 (+)	-164 bp
Tssr84738	Chr9:45049826-45049835 (+)	-91 bp
Tssr84739	Chr9:45049838-45049847 (+)	-79 bp
Tssr84740	Chr9:45049848-45049859 (+)	-68 bp
Tssr84741	Chr9:45049874-45049892 (+)	-39 bp
Tssr84742	Chr9:45049898-45049911 (+)	-17 bp
Tssr84743	Chr9:45049914-45049929 (+)	0 bp
Tssr84744	Chr9:45050045-45050056 (+)	129 bp
Tssr84745	Chr9:45050060-45050067 (+)	142 bp
Tssr84746	Chr9:45050089-45050096 (+)	171 bp
Tssr84747	Chr9:45050098-45050138 (+)	196 bp
Tssr84748	Chr9:45050162-45050178 (+)	248 bp
Tssr84749	Chr9:45050180-45050196 (+)	266 bp
Tssr84750	Chr9:45050197-45050216 (+)	285 bp
Tssr84751	Chr9:45050227-45050237 (+)	310 bp
Tssr84752	Chr9:45064234-45064237 (+)	14,314 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24