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Mcu Gene Detail
Summary
  • Symbol
    Mcu
  • Name
    mitochondrial calcium uniporter
  • Synonyms
    2010012O16Rik, Ccdc109a, D130073L02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3026965
    NCBI Gene: 215999
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:59282806-59452514 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3026965
 protein coding gene Chr10:59282806-59453231 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017258
 protein coding gene Chr10:58615471-58793186 (-)
A/J MGP_AJ_G0017235
 protein coding gene Chr10:56902882-57073308 (-)
AKR/J MGP_AKRJ_G0017194
 protein coding gene Chr10:58368314-58542740 (-)
BALB/cJ MGP_BALBcJ_G0017196
 protein coding gene Chr10:56968506-57141115 (-)
C3H/HeJ MGP_C3HHeJ_G0017019
 protein coding gene Chr10:58294441-58473274 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017654
 protein coding gene Chr10:60715809-60889651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015345
 protein coding gene Chr10:53938561-54107219 (-)
CAST/EiJ MGP_CASTEiJ_G0016590
 protein coding gene Chr10:58224289-58403966 (-)
CBA/J MGP_CBAJ_G0016991
 protein coding gene Chr10:62894615-63087287 (-)
DBA/2J MGP_DBA2J_G0017096
 protein coding gene Chr10:56212894-56384685 (-)
FVB/NJ MGP_FVBNJ_G0017090
 protein coding gene Chr10:55447007-55622032 (-)
LP/J MGP_LPJ_G0017171
 protein coding gene Chr10:58989676-59166114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017118
 protein coding gene Chr10:65414359-65593505 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017691
 protein coding gene Chr10:58180591-58356078 (-)
PWK/PhJ MGP_PWKPhJ_G0016373
 protein coding gene Chr10:56018094-56192211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016156
 protein coding gene Chr10:57526859-57699195 (-)
WSB/EiJ MGP_WSBEiJ_G0016654
 protein coding gene Chr10:58082189-58268906 (-)



Homology
more
  • Human Ortholog
    MCU, mitochondrial calcium uniporter
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCU, mitochondrial calcium uniporter
  • Synonyms
    C10orf42, CCDC109A, HsMCU
  • Links
    NCBI Gene ID: 90550
    neXtProt AC: NX_Q8NE86
    UniProt: Q8NE86

  • Chr Location
    10q22.1; chr10:72692143-72887694 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 7 genetic backgrounds
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit impaired calcium-induced permeability transition pore opening, decreased body size and weight, decreased exercise endurance and decreased grip strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009647 Ensembl Gene Model | MGI Sequence Detail 169709 C57BL/6J ±  kb
    transcript ENSMUST00000020312 Ensembl | MGI Sequence Detail 2872 Not Applicable  
    polypeptide ENSMUSP00000020312 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917124, MGI:2143778, MGI:2684910
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 67
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353781 LaMoia TE, et al., Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation. Cell Metab. 2024 Aug 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory